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GLI1 — MAPK11
Text-mined interactions from Literome
Neill et al., Cancer Res 2003
(Carcinoma, Basal Cell...) :
Furthermore, PKC regulation of
Gli1 did not
involve activation of
mitogen activated protein kinase signaling
Seto et al., Mol Carcinog 2009
(Adenocarcinoma, Mucinous...) :
Indeed,
MAPK signaling
increased the
GLI transcriptional activity and induced the expression of hedgehog target genes in gastric cancer cells ... The inductive effect of activated KRAS and mitogen activated protein/extracellular signal regulated kinase kinase ( MEK) 1 was blocked by the suppressor of fused (SUFU), indicating that
MAPK signaling
regulates GLI activity via a SUFU independent process
Atkinson et al., J Neurochem 2009
:
Selective inhibition of p38
MAPK significantly
attenuated Shh dependent up-regulation of
Gli-1 , inter-alpha trypsin inhibitor and thrombomodulin mRNA, however did not affect expression of insulin-like growth factor 2 or a novel Shh target, membrane associated guanylate kinase p55 subfamily member 6