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CASP2 — GSK3B

Text-mined interactions from Literome

Bijur et al., J Biol Chem 2000 (Neuroblastoma) : Overexpression of glycogen synthase kinase-3beta to levels 3.5 times that in control cells did not alter basal indices of apoptosis but potentiated staurosporine induced activation of caspase-3 , caspase-9, proteolysis of poly ( ADP-ribose ) polymerase, and morphological changes indicative of apoptosis ... Inhibition of glycogen synthase kinase-3beta by lithium attenuated the enhanced staurosporine induced activation of caspase-3 in cells overexpressing glycogen synthase kinase-3beta
Bijur et al., J Biol Chem 2001 : Heat shock and staurosporine treatments increased nuclear GSK-3 beta prior to activation of caspase-9 and caspase-3, and this nuclear accumulation of GSK-3 beta was unaltered by pretreatment with a general caspase inhibitor
King et al., Brain Res 2001 : MPP induced caspase-3 activity was increased by overexpression of GSK3beta ... Rotenone induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium
Stoica et al., Mol Cell Neurosci 2003 : We show that ceramide treatment initiates a cascade of biochemical alterations associated with cell death : earliest signal transduction changes involve Akt dephosphorylation and inactivation followed by dephosphorylation of proapoptotic regulators such as BAD ( proapoptotic Bcl-2 family member ), Forkhead family transcription factors, glycogen synthase kinase 3-beta , mitochondrial depolarization and permeabilization, release of cytochrome c into the cytosol, and caspase-3 activation
Watcharasit et al., J Biol Chem 2003 : After DNA damage, mitochondrial GSK3beta co-immunoprecipitated with p53 and was activated, and inhibition of GSK3beta blocked cytochrome c release and caspase-3 activation
Plate et al., Leukemia & lymphoma 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : GSK-3beta a kinase regulated via PI3-kinase dependent, down-stream kinases, was responsible for regulating cyclin D1 levels in CLL cells, but neither GSK-3beta nor calpain was responsible for induction of apoptosis, or activation of executioner caspase 3, following LY294002 treatment
Yin et al., J Biol Chem 2005 (Anoxia...) : Moreover, kallikrein promoted Bad.14-3-3 complex formation and inhibited Akt-GSK-3beta dependent activation of caspase-3 , whereas caspase-3 administration caused reduction of the Bad.14-3-3 complex, indicating an interaction between Akt-GSK-caspase-3 and Akt-Bad.14-3-3 signaling pathways
Stauffer et al., J Clin Invest 2006 (Cardiomyopathy, Dilated...) : Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta ( GSK3beta ), and caspase-3 activation
Lei et al., Biol Psychiatry 2008 (Nerve Degeneration) : Reducing GSK-3beta activity by application of selective inhibitors or depletion of GSK-3beta by siRNA attenuates caspase-3 activity and blocks PCP induced neurotoxicity
Zaheer et al., Brain Res 2008 (Neuroblastoma) : Depletion of GMF gene by introducing GMF-specific siRNA ( GsiRNA ) completely blocked both activation of GSK-3beta and caspase-3 activation whereas a control scrambled siRNA ( CsiRNA ) had no effect ... A cell-permeable peptide inhibitor of GSK-3beta , and lithium completely prevented GMF dependent activation of caspase-3
Zhang et al., Neuroreport 2008 (Brain Ischemia...) : The caspase 3-specific inhibitor, Z-DQMD-FMK, attenuated beta-catenin degradation, but it did not affect phosphorylation of both beta-catenin and glycogen synthase kinase-3beta
Sahara et al., Eur J Neurosci 2008 (Alzheimer Disease) : In SH-SY5Y neuroblastoma cells, overexpression of active JNK and GSK-3beta increased caspase-3 activation and cytotoxicity more than overexpression of tau alone
Cheng et al., Vascul Pharmacol 2010 (Disease Models, Animal...) : Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage
Jover-Mengual et al., Brain Res 2010 (Brain Ischemia...) : We demonstrate that global ischemia promotes early activation of glycogen synthase kinase-3beta ( GSK3beta ) and forkhead transcription factor of the O class ( FOXO)3A, known Akt targets that are related to cell survival, and activation of caspase-3