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CD274 — IL10

Text-mined interactions from Literome

Dong et al., Nat Med 1999 : Ligation of B7-H1 co-stimulated T-cell responses to polyclonal stimuli and allogeneic antigens, and preferentially stimulated the production of interleukin-10
Gray et al., Blood 2002 : These studies indicated that H-ferritin induced relatively greater expression of CD86 and B7-H1 on MoDCs and that monoclonal antibodies against their receptors, CTLA-4 and programmed death receptor-1 (PD-1), inhibited IL-10 production from the regulatory T cells
Tamura et al., Int J Hematol 2003 (Autoimmune Diseases...) : Upon binding to an as yet unidentified costimulatory receptor on primed T-cells, B7-H1 costimulates T-cell proliferation and preferentially induces interleukin 10 and interferon gamma
Geng et al., J Viral Hepat 2006 (Hepatitis B, Chronic) : Ligation of B7-H1 to T-cells can result in the preferential secretion of IL-10
He et al., Clin Exp Immunol 2008 (Diabetes Mellitus, Type 1) : Additionally, PD-L1/DC/GAD65 down-regulated interferon-gamma and up-regulated interleukin-10 production by activated lymphocytes
Wang et al., Eur J Immunol 2008 (Acquired Immunodeficiency Syndrome...) : In contrast, B7-H1 ligation with soluble programmed death-1 (PD-1) reduced mDC maturation and IL-12 production but increased mDC apoptosis and IL-10 production
Wen et al., Transplantation 2008 (Diabetes Mellitus, Experimental) : In addition, NIT-PD-L1 suppressed interferon-gamma but up-regulated interleukin-4 and -10 productions by those lymphocytes in vitro and in vivo
Kuang et al., J Exp Med 2009 (Carcinoma, Hepatocellular...) : Autocrine tumor necrosis factor alpha and interleukin 10 released from activated monocytes stimulated monocyte expression of PD-L1
Wu et al., Cancer Res 2009 (Carcinoma, Hepatocellular...) : Coculture of HCC cells with monocytes showed that tumor associated interleukin-10 contributed to the induction of B7-H1 in the HCC environment
Kasagi et al., J Immunol 2010 (Nephritis) : Conversely, blocking PD-L1 using an anti-PD-L1 mAb increased the number of CD4 ( + ) PD-1 ( + ) T cells in the kidney, enhanced serum IFN-gamma, IL-10 , and IgG2a ds-DNA-Ab levels, accelerated the nephritis, and increased the mortality rate
Rodríguez-García et al., J Leukoc Biol 2011 (HIV Infections) : Expression of PD-L1 was differentially modulated by IL-10, which induced up-regulation of PD-L1 but not of PD-L2, and IL-10 blockade enhanced only PD-L2 expression
Dziurzynski et al., Clin Cancer Res 2011 (Brain Neoplasms...) : The gCSCs produce CMV IL-10 , which induces human monocytes ( the precursor to the central nervous system MFs/microglia ) to assume an M2 immunosuppressive phenotype ( as manifested by downmodulation of the major histocompatibility complex and costimulatory molecules ) while upregulating immunoinhibitory B7-H1
Tamura et al., Leukemia 2013 (Multiple Myeloma...) : Among major cytokines produced by HS-5 cells, interleukin (IL)-6 induced B7-H1 expression on HMCLs
Bloch et al., Clin Cancer Res 2013 (Brain Neoplasms...) : Stimulation of monocytes with IL-10 alone could significantly increase B7-H1 expression, sufficient to induce T-cell apoptosis when cocultured with stimulated monocytes