◀ Back to ARF6
ARF6 — CYTH2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Arf6 signaling events:
ARF6/GDP complex (ARF6)
→
ARNO/beta Arrestin1-2 complex (CYTH2-ARRB2_ARRB1)
(modification, collaborate)
Claing et al., J Biol Chem 2001*
Evidence: assay, physical interaction
-
NCI Pathway Database Arf6 signaling events:
ARNO/beta Arrestin1-2 complex (CYTH2-ARRB2_ARRB1)
→
ARF6/GTP complex (ARF6)
(modification, collaborate)
Claing et al., J Biol Chem 2001*
Evidence: assay, physical interaction
-
NCI Pathway Database Arf6 signaling events:
ARNO (CYTH2)
→
ARF6/GTP complex (ARF6)
(modification, activates)
Macia et al., J Biol Chem 2001*, Santy et al., J Cell Biol 2001*, Yano et al., Mol Biol Cell 2008*, Frank et al., J Biol Chem 1998*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Arf6 signaling events:
ARF6/GTP complex (ARF6)
→
ARNO (CYTH2)
(translocation, activates)
Cohen et al., Mol Biol Cell 2007*
Evidence: assay, physical interaction
-
NCI Pathway Database Arf6 signaling events:
GNAQ/ARNO complex (GNAQ-CYTH2)
→
ARF6/GDP complex (ARF6)
(modification, activates)
Giguère et al., Cell Signal 2006*, Laroche et al., Mol Cell Biochem 2007*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Class I PI3K signaling events:
ARNO (CYTH2)
→
ARF6/GDP complex (ARF6)
(modification, activates)
Frank et al., J Biol Chem 1998*
Evidence: assay
-
NCI Pathway Database Arf6 signaling events:
IPCEF1/ARNO complex (IPCEF1-CYTH2)
→
ARF6/GDP complex (ARF6)
(modification, activates)
Venkateswarlu et al., J Biol Chem 2003
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
CYTH2
—
ARF6
Renault et al., Nature 2003*
-
IRef Bind_translation Interaction:
CYTH2
—
ARF6
(x-ray crystallography)
Renault et al., Nature 2003*
-
IRef Biogrid Interaction:
ARF6
—
CYTH2
(direct interaction, enzymatic study)
Frank et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
ARF6
—
CYTH2
(physical association, affinity chromatography technology)
Yano et al., Mol Biol Cell 2008*
-
IRef Dip Interaction:
Complex of ARF6-CYTH2-IRS1-INSR-CYTH3
(anti bait coimmunoprecipitation)
Hafner et al., Nature 2006*
-
IRef Hprd Interaction:
CYTH2
—
ARF6
(in vitro)
Frank et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
CYTH2
—
ARF6
(in vivo)
Frank et al., J Biol Chem 1998*
-
IRef Ophid Interaction:
ARF6
—
CYTH2
(aggregation, confirmational text mining)
Frank et al., J Biol Chem 1998*
-
IRef Ophid Interaction:
ARF6
—
CYTH2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Vitale et al., J Cell Biol 2002
:
Calcium regulated exocytosis of dense-core vesicles requires the
activation of
ADP-ribosylation factor (ARF)6 by
ARF nucleotide binding site opener at the plasma membrane
Jayaram et al., Biochem Pharmacol 2011
:
Arf nucleotide binding site opener [ ARNO ]
promotes sequential activation of
Arf6 , Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets ... Herein, we tested the hypothesis that
Arf nucleotide binding site opener [ ARNO ], a guanine nucleotide-exchange factor [GEF ] for the small G-protein Arf6,
mediates the functional activation of
Arf6 , and that ARNO/Arf6 signaling axis, in turn, controls the activation of Cdc42 and Rac1, which have been implicated in GSIS