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EPO — IL4

Text-mined interactions from Literome

Fandrey et al., Ann N Y Acad Sci 1991 (Carcinoma, Hepatocellular...) : A dose dependent decrease of up to 60 % in Epo production was induced by interleukin-1 beta, interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Ghinassi et al., Exp Hematol 2007 : These results suggest that interleukin-3 and erythropoietin cooperate to establish the lineage-specific transcription factor milieu of erythroid cells : interleukin-3 regulates mainly gene transcription and erythropoietin consistently increases mRNA and protein stability
Strunk et al., Acta Paediatr 2008 : Furthermore, Epo significantly inhibits the synthesis of IL-4 , IL-5 and IL-10 in adults
Lifshitz et al., Haematologica 2010 : The macrophages derived in-vitro from bone marrow cells expressed erythropoietin receptor transcripts, and in-vitro stimulation with erythropoietin activated multiple signaling pathways, including signal transducer and activator of transcription ( STAT ) 1 and 5, mitogen activated protein kinase, phosphatidylinositol 3-kinase and nuclear factor kappa B. In-vitro erythropoietin treatment of these cells up-regulated their surface expression of CD11b, F4/80 and CD80, enhanced their phagocytic activity and nitric oxide secretion, and also led to augmented interleukin 12 secretion and decreased interleukin 10 secretion in response to lipopolysaccharide
Peschel et al., Blood 1987 : BSF-1 increases the proliferation of CFU-e in the presence of recombinant erythropoietin ( rEPO )
Dybedal et al., J Immunol 1995 : Whereas IL-12 alone or in combination with Erythropoietin (Epo) showed no stimulatory effect on erythroid progenitors, IL-12 potently enhanced the number of erythroid burst forming unit ( BFU-E ) colonies formed in response to Epo+IL-4 by 63 % and Epo+stem cell factor by 80 %
Barber et al., Mol Cell Biol 1994 : Immune complex kinase assays confirmed that IL-2 and IL-4 activated JAK1 and EPO activated JAK2
Sonoda et al., Br J Haematol 1997 : IL-4 alone did not support mixed colony formation in the presence of erythropoietin (Epo)