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CASP12 — ITIH4

Text-mined interactions from Literome

Singh et al., J Neurovirol 2004 (Nerve Degeneration) : Both HIV-1 Tat and gp120 significantly increased caspase-3 activation in a concentration dependent manner in striatal neurons at 4 h following continuous exposure in vitro ... Tat ( 1-72 ) and gp120 caused significant neuronal losses at 48 h and/or 72 h. Tat ( 1-72 ) increased cytochrome c release, and caspase-3 and endo G activation at 4 h, 24 h, and/or 72 h ... By contrast, gp120 increased caspase-3 activation, but failed to increase cytochrome c or endo G levels in the cytoplasm at 4 h, 24 h, and/or 72 h
Fiala et al., Cardiovasc Toxicol 2004 (Cardiomyopathies...) : HIV-1, gp120 , or Tat induced Erk 1/2 phosphorylation, activation of caspase-3 , and apoptosis of NRVMs and CAECs ; all of these were inhibited by a MAPK/ERK-kinase (MEK) inhibitor U0126
Singh et al., Neuroscience 2005 (Nerve Degeneration) : Both Tat and gp120 caused significant increases in p38 and c-jun-N-terminal kinase mitogen activated protein kinase phosphorylation, caspase-3 activity, neurite losses and cell death in striatal neurons ... Alternatively, gp120 induced increases in caspase-3 activity, neurite losses and neuronal death were prevented by p38, but not c-jun-N-terminal kinase, mitogen activated protein kinase inhibition
Tun et al., J Neurochem 2007 : As caspase-8 induced apoptosis does not typically require p53, we examined the possibility of a novel role for p53 in caspase-8 activation initiated by gp120 ... We observed that gp120 treatment of cultured cortical neurons induced caspase-8 activity and Bid cleavage independently of p53, but induction of caspase-3 enzymatic activity required p53 expression
Alirezaei et al., J Neurosci 2007 (AIDS Dementia Complex) : PKR inactivation also inhibited gp120 induced caspase-3 activation, consistent with its neuroprotective effect
Peng et al., J Neurovirol 2008 (Neuroblastoma) : Additionally, gp120 mediated activation of caspase-3 was also significantly reduced in cells pretreated with PDGF-BB
Janda et al., Br J Pharmacol 2011 : Tianeptine showed an anti-apoptotic effect and prevented caspase-3 activation by gp120