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CASP12 — TLR3

Text-mined interactions from Literome

Mariathasan et al., Nature 2004 (Inflammation...) : Unexpectedly, Ipaf-deficient macrophages activated caspase-1 in response to TLR plus ATP stimulation but not S. typhimurium
Hewinson et al., J Immunol 2008 (Ion Channel Gating) : P2X(7) receptors ( P2X(7)Rs ) are ATP gated ion channels that trigger caspase-1 activation in the presence of TLR ligands
Maelfait et al., J Exp Med 2008 (Inflammation) : Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
Netea et al., Blood 2009 (Inflammation) : Controversy has arisen whether Toll-like receptor ( TLR ) ligands alone can activate caspase-1 for release of interleukin-1beta (IL-1beta)
Hurst et al., Immunobiology 2009 (Antiphospholipid Syndrome) : Determination of expression-levels using real-time RT-PCR showed significantly augmented TLR dependent IL-1beta and caspase-1 expression
Zorde-Khvalevsky et al., Hepatology 2009 : Furthermore, within the first hours, we observed a dramatic TLR3 dependent NF-kappaB activation and an increase in Rip3 levels in hepatocytes, accompanied by caspase-8 activation but without an apoptotic outcome
Estornes et al., Cell Death Differ 2012 : Engagement of TLR3 by dsRNA in both type I and type II lung cancer cells induces the formation of an atypical caspase-8 containing complex that is devoid of classical death receptors of the TNFR superfamily, but instead is physically associated to TLR3