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A2M — CREB5

Text-mined interactions from Literome

Misra et al., J Biol Chem 2002 : Inhibition of Ca ( 2+ ) /calmodulin kinase, protein kinases A and C, tyrosine kinases, ribosomal S6 kinase, farnesyl transferase, extracellular signal regulated kinases 1/2, phosphatidylinositol 3-kinase, or p38 mitogen activated protein kinase markedly reduce alpha(2)M* induced phosphorylation of CREB , indicating a role for the p21(ras) dependent and phosphatidylinositol 3-kinase signaling pathways in regulating CREB activation by alpha(2)M*
Qiu et al., J Biol Chem 2004 (MAP Kinase Signaling System) : We found that 1 ) phospho-MAP kinase levels were altered within 30 min after treatment with alpha2M*, 2 ) the MAP kinase inhibitor, PD98059, specifically blocked the alpha2M* induced neurite outgrowth, 3 ) manipulating intracellular calcium by BayK or BAPTA altered the neurite outgrowth and associated changes in the phospho-MAP kinase levels, which were blunted by alpha2M*, 4 ) alpha2M* promoted the phosphorylation of the transcription factor CREB through MAP kinase, and 5 ) LRP-specific antibodies increased levels of phosphorylated MAP kinase and phosphorylated CREB