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CASP2 — LMNB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wang et al., Neuroreport 1999
(Huntington Disease...) :
The cleavage of
lamin B was
inhibited by
caspase inhibitors
Gotzmann et al., J Cell Sci 2000
:
Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that LAP2 alpha was cleaved during apoptosis as rapidly as
lamin B in a
caspase dependent manner yielding stable N- and C-terminal fragments of approximately 50 and 28 kDa, respectively
Zhang et al., Proc Natl Acad Sci U S A 2001
:
Both GzmA and GzmB directly and efficiently cleave
laminB in vitro, in situ in isolated nuclei and in cells loaded with perforin and Gzms, even in the
presence of
caspase inhibitors
Boulares et al., Pharmacol Toxicol 2002
:
Acetaminophen triggered the release of cytochrome c from mitochondria into the cytosol,
activation of
caspase-3 , 8, and 9, cleavage of poly ( ADP-ribose ) polymerase, and degradation of
lamin B1 and DNA
Taimen et al., J Cell Sci 2003
:
The cleavage of NuMA,
lamin B and PARP-1 was inhibited in the
presence of three different
caspase inhibitors : z-DEVD-FMK, z-VEID-FMK and z-IETD-FMK
An et al., Int J Oncol 2003
(Burkitt Lymphoma) :
Anti-IgM triggers for cleavage of the resident nuclear proteins poly ( ADP-ribose ) polymerase ( PARP ) at 8 h, lamins B1 and B2 from 12 to 16 h ; likewise, ionomycin triggers for degradation of PARP at 2 h, lamins B1 and B2 at 4 h. Signal transduction through CD40 rescues Ramos-BL B cells from AgR- and ionomycin triggered apoptosis at a very early stage of the apoptotic process by inhibiting both the early cleavage of PARP as well as the
activation of
caspase-3 , -7 and -8 and cleavage of
lamin B1 ; CD40 mediated rescue occurs upstream of CD40 induced expression of Bcl-2 and increased expression of Bcl-xL
Almaguel et al., J Neurosci Res 2009
:
The observed cell death was apoptotic based on nuclear morphology,
caspase-3 activation , and cleavage of
lamin B and PARP