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CASP2 — NLRP5

Text-mined interactions from Literome

Frederick Lo et al., Biochem Biophys Res Commun 2008 (Brain Injuries) : In addition, transient expression of recombinant NALP1 or NALP5 in neurons induced caspase-3 activation and apoptosis ... These data suggest that NALP1 and NALP5 may regulate caspase activation and apoptosis in injured neurons, and thus represent novel molecular targets for therapeutic intervention in neurodegenerative disorders
Hedl et al., Am J Physiol Gastrointest Liver Physiol 2013 (Crohn Disease...) : Importantly, we find that, during chronic Nod2 stimulation, NLRP3/NLRP1 inflammasome mediated caspase-1 activation with subsequent IL-1 secretion is essential for the subsequent bifurcation to downregulated proinflammatory cytokines and upregulated bacterial killing