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FGF5 — NEUROD2
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Kelly et al., Cell Transplant 2003
:
As well as its role in precursor cell expansion,
FGF-2 also
plays a key role in the division of astrocytes, and in
neuronal differentiation
Heasley et al., Mol Biol Cell 1992
:
Expression of the mouse beta-PDGF receptor by gene transfer confers PDGF dependent and reversible
neuronal differentiation of PC12 pheochromocytoma cells similar to that observed in
response to NGF and basic
FGF
Jukkola et al., Dev Biol 2006
:
FGF regulated gene-expression and
neuronal differentiation in the developing midbrain-hindbrain region
Park et al., J Neurochem 2007
:
We also examined the functional role of pip92 expression during
FGF induced
neuronal differentiation in embryonic hippocampal cells
Regad et al., Nat Cell Biol 2007
:
In the mouse olfactory placode cell line OP27, and in cortical progenitors, increased
FGF signalling causes FoxG1 to exit the nucleus and
promotes neuronal differentiation , whereas FGF and Akt inhibitors block this effect
Wilcock et al., Development 2007
:
Neuron generating progenitors are also distinguished by lengthening cell cycle times, a finding supported by cell cycle acceleration on exposure to
fibroblast growth factor ( FGF ) , an
inhibitor of
neuronal differentiation
Olivera-Martinez et al., Development 2007
:
Furthermore, although
FGF inhibition of
neuronal differentiation involves repression of the RA-responsive gene, retinoic acid receptor beta (RARbeta), Wnt signals are weaker repressors of neuron production and do not interfere with RA signal transduction
Birren et al., Neuron 1990
(Cell Transformation, Viral) :
A v-myc immortalized sympathoadrenal progenitor cell line in which
neuronal differentiation is
initiated by
FGF but not NGF ... These lines initiate
neuronal differentiation in
response to basic
FGF , but not to NGF, and do not contain NGF receptor mRNA
Stemple et al., Neuron 1988
:
Basic
FGF induces
neuronal differentiation , cell division, and NGF dependence in chromaffin cells : a sequence of events in sympathetic development
Murphy et al., Development 1994
:
It was also found, in early neural crest cultures, that exogenous
FGF completely
inhibited neuronal differentiation , probably as a direct consequence of its mitogenic activity
Anderson et al., J Neurobiol 1993
:
Surprisingly, this progenitor is initially unresponsive to NGF ;
neuronal differentiation is instead
promoted by
fibroblast growth factor ( FGF )
Renaud et al., J Biol Chem 1996
:
To examine the importance of this expression on the neuronal phenotype, we have used PC12 cells, a model to study
FGF induced
neuronal differentiation
Nurse et al., Dev Biol 1997
:
Role of basic
FGF and oxygen in control of proliferation, survival, and
neuronal differentiation in carotid body chromaffin cells
Goldstein et al., J Neurobiol 1997
:
In contrast,
FGF2 prevented
neuronal differentiation and maintained a GBC phenotype