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DLK1 — NOTCH1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Notch signaling pathway: NOTCH1 heterodimer complex (NOTCH1) → DLK1 (DLK1) (modification, collaborate) Baladrón et al., Exp Cell Res 2005*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch signaling pathway: NOTCH1 heterodimer complex (NOTCH1) → NOTCH1 heterodimer/DLK1 complex (NOTCH1-DLK1) (modification, collaborate)
  Baladrón et al., Exp Cell Res 2005*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch signaling pathway: DLK1 (DLK1) → NOTCH1 heterodimer/DLK1 complex (NOTCH1-DLK1) (modification, collaborate)
  Baladrón et al., Exp Cell Res 2005*
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: DLK1 → NOTCH1 (indirect_complex) Baladrón et al., Exp Cell Res 2005*, Bray et al., BMC developmental biology 2008*, Komatsu et al., PLoS Biol 2008*
• Reactome Reaction: DLK1 → NOTCH1 (reaction) Baladrón et al., Exp Cell Res 2005*, Bray et al., BMC developmental biology 2008*, Komatsu et al., PLoS Biol 2008*
• WikiPathways Canonical and Non-canonical Notch signaling: JAG1/JAG2/DLL1/DLL3/DLL4/DLK1/DLK2/MFAP1/MFAP2/DNER/CNTN6 → NOTCH1 (mim-binding)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS Negatome - no physical interaction between proteins Interaction: DLK1 — NOTCH1 (Absence of interaction, coimunoprecipitation, MI:0110) Waddell et al., PloS one 2010*

Text-mined interactions from Literome

Bray et al., BMC developmental biology 2008 : Here we show that membrane bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes ... Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure
Tkatchenko et al., Physiol Genomics 2009 (Calcinosis...) : We found that lack of periostin in the embryonic OFT leads to ectopic expression of the proosteogenic growth factor pleiotrophin (Ptn) and overexpression of delta-like 1 homolog (Dlk1) , a negative regulator of Notch1 , in the distal ( prevalvular ) cushions of the OFT