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HES3 — NOTCH1

Text-mined interactions from Literome

Iso et al., J Cell Physiol 2003 : HES/E ( spl ) had been the only known effector of Notch signaling until a recent discovery of a related but distinct bHLH protein family, termed HERP ( HES related repressor protein, also called Hey/Hesr/HRT/CHF/gridlock )
Katoh et al., Int J Oncol 2004 : Activation of Notch signaling pathway leads to transcriptional activation of Hes family genes through the interaction between Notch intracellular domain and RBPSUH ( CSL )
King et al., Biochem Biophys Res Commun 2006 : Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa ... Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate Notch dependent activation of Hrt and Hes expression
Androutsellis-Theotokis et al., Nature 2006 (Second Messenger Systems) : Here we show that Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 (Hes3) and Sonic hedgehog (Shh) through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells
Taelman et al., Development 2006 : Here, we show that the Xenopus Hairy related transcription factor ( HRT ) gene XHRT1, and the Hairy/Enhancer of split ( HES ) genes Xhairy1, Xhairy2b, esr9 and esr10, have distinct restricted dynamic expression patterns during pronephros development, and that their expression is regulated by Notch
Katoh et al., Int J Oncol 2008 : P53 induced NOTCH1 upregulation leads to HES1, HES5 , HEY1, HEY2 or HEYL upregulation for the repression of tissue specific bHLH transcriptional activators
Batts et al., Hear Res 2009 : These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and Notch dependent Hes activity in response to cellular trauma and that the signaling is transient
Kubo et al., Development 2009 : Interestingly, unlike other developmental contexts in which Hes gene expression is regulated by Notch signaling, Hairy1 expression in the CMZ is regulated by Wnt signaling
Albright et al., J Pharmacol Exp Ther 2013 : Measurements of Notch related toxicity included goblet cell metaplasia in the gut, marginal-zone depletion in the spleen, reductions in B cells, and changes in expression of the Notch regulated hairy and enhancer of split homolog-1 from blood cells