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NOTCH1 — POFUT1

Pathways - manually collected, often from reviews:

• Reactome Reaction: NOTCH1 → POFUT1 (reaction) Wang et al., J Biol Chem 2001*, Shao et al., J Biol Chem 2003*, Okajima et al., Science 2005*, Stahl et al., J Biol Chem 2008*, Yao et al., Blood 2011*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: POFUT1 — NOTCH1 (in vivo) Shi et al., Proc Natl Acad Sci U S A 2003*

Text-mined interactions from Literome

Okajima et al., J Biol Chem 2003 : O-Fucosylation is mediated by protein O-fucosyltransferase 1 , and down-regulation of this enzyme by RNA interference or mutation of the Ofut1 gene in Drosophila or by mutation of the Pofut1 gene in mouse prevents Notch signaling
Stahl et al., J Biol Chem 2008 : Therefore, mammalian Notch receptors require Pofut1 for the generation of optimally functional Notch receptors, but, in contrast to Drosophila, Pofut1 is not required for stable cell surface expression of Notch ... Therefore, mammalian Notch receptors require Pofut1 for the generation of optimally functional Notch receptors, but, in contrast to Drosophila, Pofut1 is not required for stable cell surface expression of Notch
Okamura et al., Mech Dev 2008 (Cardiovascular Abnormalities) : These defects were still evident in NICD1 expressing embryos irrespective of the presence or absence of Pofut1, which indicates that Pofut1 is required for Notch signaling upstream of NICD1