Jeon et al., J Cell Sci 2006
:
In addition, SPC increased secretion of TGF-beta1 through an ERK dependent pathway, and the SPC induced expression of alpha-SMA and delayed phosphorylation of Smad2 were blocked by SB-431542, a TGF-beta type I receptor kinase inhibitor, or anti-TGF-beta1 neutralizing antibody
Morishita et al., J Neurochem 2007
:
Whereas endothelin consistently activated RhoA, TGF-beta did not, and a specific inhibitor of TGF-beta type I receptor blocked TGF-beta enhanced SMA promoter activity, suggesting involvement of Smad phosphorylation