Gene interactions and pathways from curated databases and text-mining

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PSMA2 — PSMB8

Pathways - manually collected, often from reviews:

  • Reactome Reaction: PSMA2 → PSMB8 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jang et al., Oncogene 1999 : Three negative growth regulators, the HMG-CoA reductase inhibitor lovastatin, the antimetabolite 5-fluorouracil, and the cyclic nucleotide dibutyryl cAMP were found to induce cell type-specific loss of p107 protein which was reversible by the calpain inhibitor leucyl-leucyl-norleucinal but not by the serine protease inhibitor phenylmethylsulfonylfluoride, caspase inhibitors, or lactacystin, a specific inhibitor of the 26S proteasome
Lange et al., Proc Natl Acad Sci U S A 2000 (Breast Neoplasms...) : Lactacystin and calpain inhibitor I, specific inhibitors of the 26S proteasome , blocked progestin induced down-regulation, and ubiquitinated conjugates of PR accumulated in cells
Lee et al., Mol Cell Biol 2000 : Inhibition of 26S proteasome activity by the use of lactacystin or MG132 completely blocked IGF mediated degradation of IRS-1 ... Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition
Mao et al., Proc Natl Acad Sci U S A 2000 : Ubiquitin/26S proteasome dependent degradation of topoisomerase I (TOP1) has been suggested to be a unique repair response to TOP1 mediated DNA damage
Lonard et al., Mol Cell 2000 : The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation
Reverte et al., Dev Biol 2001 : CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome
Kaufmann et al., J Biol Chem 2001 : In CHO-K1 cells, cyclin A processing to cyclin A ( t ) occurs at the N terminus ; it does not involve the 26 S proteasome , nor could it be induced by conditional overexpression of the cyclin dependent kinase inhibitor p27 ( Kip1 )
Hammond et al., Oncogene 2001 : In many cell types the ligand dependent degradation of the tyrosine kinase receptor Met is completely dependent on the activity of the 26S proteasome ( Jeffers et al., 1997b )
Desai et al., Cancer Res 2001 (Breast Neoplasms...) : Ubiquitin/26S proteasome mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells
Nag et al., Mol Cell Biol 2001 : Moreover, we find that an inhibitor of 26S proteasome increases the level of DDB2 , suggesting that it is regulated by the ubiquitin-proteasome pathway
Löw et al., Acta Biol Hung 2001 : These observations underline the role of 26S proteasome in programmed cell death
Echarri et al., Curr Biol 2001 : Moreover, inhibition of the 26S proteasome leads to increased c-Abl levels in vitro and in cells, and activated c-Abl proteins are ubiquitinated in vivo
van Laar et al., Mutat Res 2002 : On the basis of its localization in the ER-membrane, it is hypothesized that Mif1 could play a role in the translocation of the 26S proteasome towards the ER-membrane, thereby enhancing ER-associated protein degradation
Inai et al., Arch Biochem Biophys 2002 : Nondenaturing gel electrophoresis followed by activity staining revealed that Delta rpn9 yeast cells had a higher activity of 20 S proteasome than wild type and that in both Delta rpn9 and wild-type cells treated with hydrogen peroxide, 20 S proteasome activity was increased with a concomitant decrease in 26 S proteasome activity
Witko-Sarsat et al., J Biol Chem 2002 : Inhibition of the 26 S proteasome by lactacystin or of caspases by benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone did not inhibit p21 proteolysis
Zhang et al., J Biol Chem 2003 (Cell Transformation, Neoplastic...) : PAX3-FKHR transformation increases 26 S proteasome dependent degradation of p27Kip1 , a potential role for elevated Skp2 expression
Xiao et al., Proc Natl Acad Sci U S A 2003 : It has been proposed that the topoisomerase II (TOP2)beta-DNA covalent complex arrests transcription and triggers 26S proteasome mediated degradation of TOP2beta
Parcellier et al., Mol Cell Biol 2003 : The interaction of HSP27 with the 26S proteasome is required to activate the proteasome and the degradation of phosphorylated I-kappaBalpha
Tatsumi et al., J Biol Chem 2003 : Furthermore, the 26 S proteasome inhibitor MG132 blocks the decrease in ORC1 , suggesting that the ORC1 cycle is mainly due to 26 S proteasome dependent degradation
Henriksen et al., Oncogene 2003 (Osteosarcoma) : In sarcomas, the TP53 tumour suppressor pathway may be altered either by TP53 mutations or by amplification of MDM2, encoding a protein that inhibits TP53 and targets it for 26S-proteasome degradation
Nasizadeh et al., Cell Physiol Biochem 2003 : The degradation of C. fasciculata ODC in the mammalian systems is markedly reduced by inhibition of the 26S proteasome
Stipanuk et al., Am J Physiol Endocrinol Metab 2004 (Carcinoma, Hepatocellular) : Inhibitors of the 26S proteasome blocked CDO degradation in cysteine-deficient cells but had little or no effect on CDO concentration in hepatocytes cultured with excess cysteine
Li et al., Cancer Res 2003 (Colonic Neoplasms...) : Indeed, ARC-111, like CPT, was shown to induce reversible TOP1 cleavage complexes in tumor cells as evidenced by specific reduction of the TOP1 immunoreactive band in a band depletion assay, as well as elevation of small ubiquitin modifier-TOP1 conjugate levels and activation of 26S proteasome mediated degradation of TOP1
Li et al., Arch Virol 2004 : 26S proteasome inhibitor, lactacystin prevented the degradation of P42 as well as M1 ', but not that of P44 efficiently, suggesting that P44 is degraded by another protease besides the 26S proteasome
Xiao et al., J Biol Chem 2004 : The phosphorylation of these specific serines is the prerequisite for ubiquitination and subsequent processing of p100 mediated by the beta-TrCP ubiquitin ligase and 26 S proteasome , respectively
Shibuya et al., Life Sci 2004 : BAY11-7082, an inhibitor of nuclear factor kappaB (NF-kappaB) activation, and MG132, a 26S proteasome inhibitor, reduced the TPA induced ICAM-1 expression but not the IFN-gamma induced one
Park et al., FEBS Lett 2004 : Expression of c-IAP1 and c-IAP2 decreased the steady-state level of RIP, which was blocked by inhibition of the 26S proteasome ... Expression of c-IAP1 and c-IAP2 decreased the steady-state level of RIP, which was blocked by inhibition of the 26S proteasome
Lin et al., Mol Pharmacol 2004 : We found that berberine induced HIF-1alpha degradation was blocked by a 26S proteasome inhibitor
Jakob et al., Genes Chromosomes Cancer 2005 (Breast Neoplasms...) : This change accelerates 26S proteasome mediated degradation of both endogenous and exogenous mutant SMAD4
Akiyama et al., Matrix Biol 2005 : Here we show that inhibitors of the 26S proteasome increase both the levels of Sox9 protein and its transcriptional activity measured with Col2a1 promoter/enhancer construct in RCS cells and C3H10T1/2 cells
Zhang et al., J Biol Chem 2005 : Degradation of Keap1 is independent of the 26 S proteasome, because inhibitors of the 26 S proteasome do not prevent loss of Keap1 following exposure of cells to quinone induced oxidative stress
Tao et al., Plant Cell 2005 : Auxin signaling relies on ubiquitin ligase SCF ( TIR1 ) -mediated 26S proteasome dependent proteolysis of a large family of short lived transcription regulators, auxin/indole acetic acid ( Aux/IAA ), resulting in the derepression of auxin-responsive genes
Shen et al., Plant J 2005 : Inhibitors of the 26S proteasome increased the stability of PIF1 , indicating that degradation of PIF1 is mediated by the ubiquitin-26S proteasome pathway
Matsunobu et al., Cancer Res 2006 (Cell Transformation, Neoplastic...) : These findings indicate an important role of EWS-Fli1 in the prevention of senescence, leading to the unlimited growth and oncogenesis of EFT cells through a decrease in the stability of p27 protein due to increased action of Skp2 mediated 26S proteasome degradation
Santer et al., Cancer Res 2006 (Bone Neoplasms...) : We show that IGFBP-3 degradation depends on an active ubiquitin-E1 ligase, specific 26S proteasome inhibitors can efficiently stabilize nuclear IGFBP-3 , and the metabolic half-life of nuclear IGFBP-3 is strongly reduced relative to cytoplasmic IGFBP-3
Villamar-Cruz et al., Brain Res Bull 2006 : In this work we have determined the role of the 26S proteasome in the regulation of the content of progesterone receptors ( PR-A and PR-B ), estrogen receptors ( ER-alpha and ER-beta ), the coactivator SRC-1 and the corepressor SMRT in the rat brain during the estrous cycle
Tan et al., J Burn Care Res 2006 (Burns) : Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice ... The results showed that TNF-alpha and burn can markedly increased the activities and contents of 26S proteasome and 19S regulator in mice skeletal muscle
Quadrini et al., FEBS Lett 2006 : Herein, we determine that 26S proteasome inhibitors lead to an accumulation of EKLF protein in murine erythroleukemia (MEL) cells
Dai et al., J Biol Chem 2006 : We further show that L11 inhibited 26 S proteasome mediated degradation of ubiquitinated MDM2 in vitro and consistently prolonged the half-life of MDM2 in cells
Fribley et al., Cancer Biol Ther 2006 (Neoplasms) : Activation of the transcription factor nuclear factor kappa B (NF-kappaB) , a key survival factor, is dependent on the 26S proteasome
Peterson et al., J Mol Biol 2006 : Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome
Block et al., J Biol Chem 2007 : Inhibition of the 26 S proteasome in VHL expressing cells increased p22phox protein levels, which correlated with an increase of NADPH dependent superoxide generation
Muñoz et al., Neurobiol Aging 2008 (Alzheimer Disease...) : The increased phosphorylation of p27 at Thr187, rather than changes in the 26S proteasome activity, is likely responsible for the enhanced degradation of p27 in AD cells
Kristiansen et al., Mol Cell 2007 (Nerve Degeneration...) : By challenge with recombinant prion and other amyloidogenic proteins, we demonstrate that only the prion protein in a nonnative beta sheet conformation inhibits the 26S proteasome at stoichiometric concentrations
Mandrekar et al., J Immunol 2007 (Inflammation) : Alcohol induced degradation of IkappaBalpha in the presence of a 26S proteasome inhibitor suggested proteasome independent IkappaBalpha degradation
Xu et al., Circulation 2007 (Diabetes Mellitus, Experimental) : Furthermore, adenoviral overexpression of superoxide dismutase and inhibition of endothelial nitric oxide synthase with N ( G ) -nitro-L-arginine methyl ester significantly attenuated the high glucose induced activation of 26S proteasome and the reduction of GTPCH ... Furthermore, adenoviral overexpression of superoxide dismutase and inhibition of endothelial nitric oxide synthase with N ( G ) -nitro-L-arginine methyl ester significantly attenuated the high glucose induced activation of 26S proteasome and the reduction of GTPCH
Yerlikaya et al., Biochem J 2008 : Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem regulated inhibitor ( HRI ) kinase
Smith et al., Am J Physiol Endocrinol Metab 2008 (Sepsis...) : Other important consequences of calpain activation that may contribute to muscle wasting during sepsis include degradation of certain transcription factors and nuclear cofactors, activation of the 26S proteasome , and inhibition of Akt activity, allowing for downstream activation of Foxo transcription factors and GSK-3beta
Kendrick et al., Curr Opin Plant Biol 2008 : In the nucleus, EIN3-BINDING F-BOX1 and 2 (EBF1/2) coordinately control 26S proteasome degradation of the critical transcription factors EIN3 and EIL1
Tonoki et al., Mol Cell Biol 2009 (Nerve Degeneration) : Rpn11 overexpression suppressed the age related reduction of the 26S proteasome activity, resulting in the extension of flies ' life spans with suppression of the age dependent accumulation of ubiquitinated proteins
Yu et al., Plant Cell 2009 : Consistent with this interpretation, we showed that both GFP-CRY2 and endogenous CRY2 formed nuclear bodies in the presence of the 26S-proteasome inhibitors that block blue light dependent CRY2 degradation
Stuttmann et al., J Biol Chem 2009 : These results are consistent with CSN dependent protection of Arabidopsis CRLs from autocatalytic degradation, as observed in other eukaryotes, and provide evidence for antagonist roles of the CSN and 26S proteasome in modulating accumulation of the plant CRL SCF ( TIR1 )
Book et al., Plant Cell 2009 : Collectively, the data point to a specific role for RPN5 in the plant 26S proteasome and suggest that its two paralogous genes in Arabidopsis have both redundant and unique roles in development
Funakoshi et al., Cell 2009 : Nas2 forms a complex with the Rpt4 and Rpt5 ATPases and enhances 26S proteasome formation in vivo and in vitro
Wei et al., Am J Physiol Cell Physiol 2009 : Surprisingly, IkappaBalpha degradation is independent of IKK ( IkappaB kinase ) and the 26S proteasome
Thompson et al., J Biol Chem 2009 : Subcomplexes of PA700 , the 19 S regulator of the 26 S proteasome , reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activity
Xu et al., Hypertension 2009 (Hypertension) : Genetic inhibition of NAD ( P ) H oxidase or administration of uric acid ( a peroxynitrite scavenger ) or N ( G ) -nitro-l-arginine methyl ester ( nonselective NO synthase inhibitor ) significantly attenuated Ang II-induced PA700 nitration, 26S proteasome activation, and reduction of GTP cyclohydrolase I and BH4 ... Genetic inhibition of NAD ( P ) H oxidase or administration of uric acid ( a peroxynitrite scavenger ) or N ( G ) -nitro-l-arginine methyl ester ( nonselective NO synthase inhibitor ) significantly attenuated Ang II-induced PA700 nitration, 26S proteasome activation , and reduction of GTP cyclohydrolase I and BH4
Bruns et al., Traffic 2010 (Neovascularization, Pathologic) : This novel VEGFR2 proteolysis was blocked by the inhibitors of 26S proteasome activity
Powers et al., Oncogene 2010 (Breast Neoplasms) : Protein levels of ERalpha are tightly controlled by the 26S proteasome ; yet, how the clinical proteasome inhibitor, bortezomib, affects ERalpha regulation has not been studied
Kuranaga et al., Rinshō shinkeigaku = Clinical neurology 2009 (Neurodegenerative Diseases) : Rpn11 overexpression suppressed the age related reduction of the 26S proteasome activity, resulting in the extension of flies ' life spans with suppression of the age dependent accumulation of ubiquitinated proteins
Nishizawa-Yokoi et al., Plant Cell Physiol 2010 : To clarify the signal transduction pathway involved in the regulation of HsfA2 expression, we investigated the effect of MG132, a 26S proteasome inhibitor, or geldanamycin (GDA), a heat shock protein 90 (Hsp90) inhibitor , on the transcription of HsfA2 and its targets, Hsp18.1-CI and ascorbate peroxidase 2 ( Apx2 ), in Arabidopsis T87 cells
Wang et al., Circ Res 2010 : Analysis of aortic endothelial cells from AMPKalpha2 ( -/- ) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of AMPK activity increased NAD ( P ) H oxidase subunit expression ( gp91(phox), p47(phox), p67(phox), NOX1 and -4 ), NAD ( P ) H oxidase mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of NF-kappaB ( p50 and p65 ), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect ... Consistently, we found that genetic deletion of AMPKalpha2 in low-density lipoprotein receptor knockout ( LDLr ( -/- ) ) strain markedly increased 26S proteasome activity, IkappaB degradation, NF-kappaB transactivation , NAD ( P ) H oxidase subunit overexpression, oxidative stress, and endothelial dysfunction, all of which were largely suppressed by chronic administration of MG132, a potent cell permeable proteasome inhibitor
Méndez-Ferrer et al., Ann N Y Acad Sci 2010 : Here, we show that beta-AR stimulation in stromal cells causes Sp1 degradation, partially mediated by the 26S proteasome
Alfano et al., J Clin Endocrinol Metab 2010 : 17-AAG induced a 26S proteasome dependent degradation of wild-type RET and MEN2 associated RET mutants
Li et al., PloS one 2010 : HIV-1 replication through hHR23A mediated interaction of Vpr with 26S proteasome
Lu et al., Plant J 2010 : FUS3 degradation follows the 26S proteasome in vitro and in vivo, and the CTD affects its degradation rate ... FUS3 degradation follows the 26S proteasome in vitro and in vivo, and the CTD affects its degradation rate
Guo et al., J Biol Chem 2010 : In this regard, using a murine macrophage model of LPS stimulation, we previously demonstrated that osteopontin (OPN) increased STAT1 ubiquitination and 26 S proteasome degradation via the ubiquitin E3 ligase, PDLIM2
Shang et al., Free Radic Biol Med 2011 : In the canonical UPP , both ubiquitin and the 26S proteasome are involved
Mookerjee et al., Biochim Biophys Acta 2011 : We show here that rapid degradation of UCP3 in vitro in isolated brown adipose tissue mitochondria required the 26S proteasome , ubiquitin, ATP, succinate to generate a high membrane potential, and a pH of 7.4 or less
Lyzenga et al., Plant J 2012 : Here we demonstrate in planta that ACS7 is turned over in a 26S proteasome dependent manner and that degradation of ACS7 requires the E3 ligase XBAT32
Rodriguez et al., PloS one 2012 : Native gel electrophoresis of the whole tissue lysates showed that the 20S proteasome was more active in the longer lived species and that 26S proteasome was both more active and more populous
Lin et al., Plant Signal Behav 2012 : Based on the reduced abundance of RP2-CP in rpn10-2 and a role of RPN10 in lid-base association, a structural role of RPN10 in 26S proteasome stability is likely to be more relevant in vivo
Samaras et al., Biochem Biophys Res Commun 2012 : 26S proteasome regulation of Ankrd1/CARP in adult rat ventricular myocytes and human microvascular endothelial cells ... 26S proteasome regulation of Ankrd1/CARP in adult rat ventricular myocytes and human microvascular endothelial cells
Vlachostergios et al., Cell Mol Neurobiol 2013 (Brain Neoplasms...) : MGMT is post-translationally regulated by the 26S proteasome , a multi-subunit organelle responsible for degradation of misfolded cellular proteins
Vaeteewoottacharn et al., J Cancer Res Clin Oncol 2013 (Bile Duct Neoplasms...) : Therefore, bortezomib (BTZ) , a specific 26S proteasome inhibitor , was selected, and its antitumor effects against CCA were investigated
Ebisui et al., Clin Sci (Lond) 1995 : Interleukin-6 ( 100 units/ml ) increased the activity of 26S proteasome by 31.5 %, of cathepsin B by 53.5 % and of cathepsin B+L by 21.3 %
Conner et al., J Pharmacol Exp Ther 1997 (Chronic Disease...) : The objectives of this study were to ( 1 ) assess the role of the 26S proteasome complex in regulating the expression of the inducible isoform of nitric oxide synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) in a model of chronic granulomatous colitis in vivo and ( 2 ) determine the role of the proteasome in regulating the inflammatory response observed in this model of chronic gut inflammation ... The objectives of this study were to ( 1 ) assess the role of the 26S proteasome complex in regulating the expression of the inducible isoform of nitric oxide synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) in a model of chronic granulomatous colitis in vivo and ( 2 ) determine the role of the proteasome in regulating the inflammatory response observed in this model of chronic gut inflammation
Weinstein et al., J Biol Chem 1997 : Inhibition of the 26 S proteasome prevented both mitotic exit and loss of p55Cdc at the M/G1 transition, suggesting that p55Cdc degradation was mediated by the cell cycle regulated proteolytic pathway
Grisham et al., Methods Enzymol 1999 (Arthritis...) : Inhibition of NF-kappa B activation in vitro and in vivo : role of 26S proteasome