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BDNF — CASP4
Text-mined interactions from Literome
Kurokawa et al., Invest Ophthalmol Vis Sci 1999
(Reperfusion Injury) :
BDNF diminishes
caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia
Han et al., Neurobiol Dis 2000
(Brain Ischemia...) :
BDNF blocks
caspase-3 activation in neonatal hypoxia-ischemia ... Utilizing a specific molecular marker of an apoptotic pathway, these findings demonstrate that H-I injury to the developing brain is a strong apoptotic stimulus leading to caspase-3 activation, that BDNF can block this process in vivo, and that the ability of
BDNF to
inhibit caspase activation and subsequent apoptosis likely accounts in large part for its protection against neuronal injury in this model
Klöcker et al., J Neurosci 2000
(MAP Kinase Signaling System) :
Furthermore, we provide evidence that
BDNF suppresses cleavage and enzymatic activity of the neuronal cell death effector
caspase-3
Ukai et al., J Neural Transm 2004
:
Moreover,
brain derived neurotrophic factor (BDNF)
reduced the
caspase-3 activity and protected neurons from haloperidol induced apoptosis
Bifrare et al., J Infect Dis 2005
(Disease Models, Animal...) :
Brain derived neurotrophic factor (BDNF) blocks activation of
caspase-3 , reduces translocation of apoptosis inducing factor ( AIF ), attenuates excitotoxicity of glutamate, and increases antioxidant enzyme activities
Pérez-Navarro et al., J Neurochem 2005
:
Brain derived neurotrophic factor prevents changes in Bcl-2 family members and
caspase-3 activation induced by excitotoxicity in the striatum
Zhang et al., Brain Res 2006
(Brain Ischemia...) :
This combination could also significantly ameliorate DWI of MRI and behavior examination results, and promote the expression of
BDNF and
inhibit the expression of
caspase-3
Zhao et al., Neurosci Lett 2009
:
Furthermore, inactivating
BDNF also
attenuated the suppression by ASC-CM of glutamate induced
caspase-3 activity, but not p38 phosphorylation
Cao et al., Brain Res Bull 2011
(Brain Ischemia...) :
Further investigation demonstrated that treatment with baicalin remarkably promoted the expression of
BDNF and
inhibited the expression of
caspase-3 at mRNA and protein levels by real-time RT-PCR and Western blot, respectively