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Böl et al., Biofactors 1999
(Thymoma...) :
Stimulation of the Interleukin-1 receptor type I (IL-1-RI) with IL-1 activates an associated serine/threonine kinase , IRAK, which phosphorylates downstream targets, resulting in NFkappaB activation
Lee et al., J Biol Chem 1994
:
Genistein, at an unsaturating dose, plus a serine/threonine kinase inhibitor, H7, completely blocked the autocrine induction of IL-1 alpha suggesting that expression of this gene is regulated by tyrosine kinase ( s ) in combination or independently with serine/threonine kinase ( s )