Kemper et al., Cancer Chemother Pharmacol 2004
:
We determined the effect of zosuquidar.3HCl , an inhibitor of P-gp , on the penetration of the anticancer drug paclitaxel into the brain ... Zosuquidar.3HCl also increased the paclitaxel concentrations in plasma and tissues to levels similar to those observed in P-gp knockout mice, suggesting selective P-gp inhibition of zosuquidar.3HCl Morschhauser et al., Leukemia & lymphoma 2007
(Lymphoma, Non-Hodgkin) :
A phase I/II trial was performed to investigate the safety and tolerance of zosuquidar.3HCL , a potent inhibitor of P-glycoprotein (P-gp) , when administered orally alone and in combination with the CHOP regimen in patients with untreated non-Hodgkin 's lymphoma and to determine whether zosuquidar.3HCL affects pharmacokinetics of doxorubicin and vincristine