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EZR — PRKACG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhou et al., J Biol Chem 2003
:
In addition, expression of S66A mutant ezrin in cultured parietal cells attenuates the dilation of apical vacuolar membrane associated with stimulation by histamine, indicating that
PKA mediated phosphorylation of
ezrin is necessary for acid secretion ... These data suggest that
PKA mediated phosphorylation of
ezrin plays an important role in mediating the remodeling of the apical membrane cytoskeleton associated with acid secretion in parietal cells
Wang et al., Biochem Biophys Res Commun 2005
:
Our recent studies demonstrate the functional relevance of
PKA mediated phosphorylation of
ezrin in parietal cell secretion [ R. Zhou, X. Cao, C. Watson, Y. Miao, Z. Guo, J.G. Forte, X. Yao, Characterization of protein kinase A-mediated phosphorylation of ezrin in gastric parietal cell activation, J. Biol. Chem. 278 ( 2003 ) 35651 ]
Jin et al., Biochem Biophys Res Commun 2006
:
In addition, our study shows that
PKA mediated phosphorylation of
ezrin is essential and sufficient for the apical localization of WWOX protein as disruption of ezrin-WWOX interaction eliminated the apical localization of WWOX
Wang et al., Cell Res 2009
(Neoplasms) :
Importantly,
PKA mediated phosphorylation of
ezrin promotes the NK cell internalization process