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RAC1 — WNT6

Text-mined interactions from Literome

Habas et al., Genes Dev 2003 : Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK) ... Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the Wnt induced Dvl-Rho complex
Esufali et al., Oncogene 2004 : Expression of dominant negative ( N17 ) Rac1 mutant in colon cancer cells caused a marked inhibition of Wnt signaling, as determined by the TCF/LEF-responsive ( TOPFLASH ) transcription assay
Habas et al., Methods Enzymol 2006 : Activation of Rho and Rac by Wnt/frizzled signaling ... Wnt/Fz activation of the small GTPases Rho and Rac has emerged as a key mechanism that regulates cell polarity and movements during vertebrate gastrulation ... In this chapter, we describe biochemical assays for the detection of Wnt/Fz activation of Rho and Rac in both mammalian cells and Xenopus embryo explants
Shi et al., Mol Cell Biol 2006 : Noncanonical Wnt/Fz signaling activates RhoA and Rac , and the latter triggers the activation of c-Jun N-terminal kinase (JNK)
Esufali et al., Cancer Res 2007 (Colorectal Neoplasms) : This prompted us to investigate if Rac1b , frequently overexpressed in colon tumors, contributes to Wnt pathway dysregulation
Esufali et al., FEBS Lett 2007 : We have previously shown that the NLS activity of Rac1 and the Rac1b splice variant is essential for Wnt pathway activation
Upadhyay et al., Oncogene 2008 : Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling ... We report that DOCK4, a guanine nucleotide exchange factor (GEF) for Rac and a member of the CDM family of unconventional GEFs, mediates Wnt induced Rac activation in the canonical Wnt/beta-catenin pathway ... Furthermore, we observe that DOCK4 is phosphorylated by GSK3beta, which enhances Wnt induced Rac activation
Buongiorno et al., Molecular cancer 2008 : This association served to facilitate transcription, since overexpression of active Rac1 augmented Wnt target gene activation, whereas depletion of endogenous Rac1 by RNA interference abrogated this effect
Bosco et al., Oncogene 2010 : Thus, Rac1 mediated canonical Wnt signaling is essential for the loss of contact inhibition in NF2-deficient cells
Mezzacappa et al., Methods Mol Biol 2012 : The Rho family of small GTPases are activated and required for non-canonical Wnt signaling during gastrulation, and in this chapter, we describe biochemical assays for the detection of Wnt mediated activation of Rho, Rac , and Cdc42 in both mammalian cells and Xenopus embryo explants