◀ Back to OSM

CXCL12 — OSM

Text-mined interactions from Literome

Lafontant et al., Am J Physiol Cell Physiol 2006 : In an effort to assess possible roles of OSM in the myocardium, we used cardiac fibroblasts ( mCFs ) isolated from adult mouse heart to determine whether recombinant murine OSM regulates the synthesis and release of MIP2/CXCL2, KC/CXCL1 , and LIX/CXCL5, which are three potent neutrophil chemoattractants in the mouse
Lee et al., Int J Biochem Cell Biol 2007 (MAP Kinase Signaling System) : The OSM stimulated expression of SDF-1 in hATSCs was completely abrogated by pretreatment of the cells with U0126, an MEK-specific inhibitor, but not with AG490, a JAK2 inhibitor, or WHI-P131, a JAK3 inhibitor, suggesting that ERK, but not JAK2 and JAK3, is involved in the OSM induced expression of SDF-1 ... Pretreatment of hATSCs with anti-VEGF neutralizing antibody or VEGF receptor inhibitors, SU5416 and KRN633, had no significant impact on the OSM induction of SDF-1 ... These results suggest that OSM induces secretion of SDF-1 through ERK-, but not VEGF-, dependent signaling pathways in mesenchymal stem cells
Hohensinner et al., FASEB J 2009 (Inflammation) : Our data, showing that OSM induces SDF-1 protein secretion in human cardiac cells in vitro and murine hearts in vivo, suggest that OSM via the induction of SDF-1 might play a key role in repair and tissue regeneration