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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PARP16

Text-mined interactions from Literome

Frouin et al., J Biol Chem 2003 : Unexpectedly, PARP-1 activity also decreased in the presence of p21waf1/cip1
Rosato et al., Mol Pharmacol 2004 : Enforced expression of p21 ( WAF1/CIP1 ) ( i.e., in Jurkat cells inducibly expressing p21 ( WAF1/CIP1 ) under the control of a doxycycline-responsive promoter ) partially but significantly reduced cytochrome c and apoptosis inducing factor release, loss of mitochondrial membrane potential, caspase-3 and -8 activation, Bid cleavage, poly ( ADP-ribose ) polymerase ( PARP ) degradation, and apoptosis in response to SB/FP
Li et al., J Biol Chem 2005 : Both p21 ( waf1/cip1 ) antisense and small interfering RNA could restore apoptotic associated caspase 3 activity, PARP activation, and sensitivity to mitomycin induced apoptosis
Madison et al., Oncogene 2010 : PARP inhibition attenuated activation of p21 transcription by both p53 independent and p53 dependent processes, in a CtBP dependent manner