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TLR2 — WNT3
Text-mined interactions from Literome
Bansal et al., J Biol Chem 2011
(Bacterial Infections) :
Interestingly, inducible NOS (iNOS) activity is pivotal for
TLR2 mediated activation of
Wnt-ß-catenin signaling as iNOS ( -/- ) mice demonstrated compromised ability to trigger activation of Wnt-ß-catenin signaling as well as Notch1 mediated cellular responses
Yi et al., PloS one 2012
:
With respect to mechanism,
TLR4 suppressed
Wnt signaling, decreased phosphorylation and activation of the Wnt receptor LRP6, and blocked the protective effect of the Wnt3a ligand