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BMP7 — MAPK9
Text-mined interactions from Literome
Viñals et al., FEBS Lett 2002
:
In contrast,
BMP-2 had no effect on p42/p44
MAPK ( Erks ) stimulation
Cox et al., Brain Res 2004
(MAP Kinase Signaling System) :
Western blot analysis indicated that
BMP7 increased phosphorylation of p42,44
MAPK and PKC ... The protective
effects of
BMP7 may involve the activation of p42,44
MAPK and PKC
Leung-Hagesteijn et al., Mol Cell Biol 2005
:
To investigate the role of ILK in BMP7 signaling, we showed that ILK overexpression increased basal and
BMP7 induced levels of phospho-p38 (
MAPK ) and phospho-ATF-2 ... Consistent with its inhibitory effects on IMCD-3 cell morphogenesis, expression of ILK ( E359K ) blocked
BMP7 dependent increases in phospho-p38 (
MAPK ) and phospho-ATF-2
Otani et al., American journal of physiology. Renal physiology 2007
:
Antagonistic effects of
bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation
induced by aldosterone through
MAPK activation
Takahashi et al., J Endocrinol 2008
:
Bone morphogenetic protein 6 (BMP6) and
BMP7 inhibit estrogen induced proliferation of breast cancer cells by
suppressing p38
mitogen activated protein kinase activation ... Estradiol rapidly activated
MAPK phosphorylation including extracellular signal regulated kinase 1/2, p38, and stress activated protein kinase/c-Jun NH2-terminal kinase pathways and BMP6,
BMP7 , and activin preferentially
inhibited estradiol induced p38 phosphorylation
Leong et al., PloS one 2009
(Osteoporosis) :
These results indicate that protein palmitoylation plays an important role in
BMP induced
MAPK activation, osterix expression, and osteoblast differentiation
Ortega et al., Cereb Cortex 2010
(MAP Kinase Signaling System) :
BDNF/MAPK/ERK induced
BMP7 expression in the developing cerebral cortex induces premature radial glia differentiation and impairs neuronal migration
Yamanaka et al., Hypertens Res 2010
(Hypertension, Pulmonary) :
Notably, ET1- and aldosterone induced mitosis and
mitogen activated protein kinase phosphorylation were significantly increased in the
presence of BMP-2 and
BMP-7 in PASMCs isolated from idiopathic PAH, although additive effects were not observed in PASMCs isolated from secondary PAH
Ge et al., J Bone Miner Res 2012
(MAP Kinase Signaling System) :
Significantly, in the presence of AA,
BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally
dependent on
ERK/MAPK activity
Ebeling et al., Reprod Fertil Dev 2011
:
Furthermore,
BMP-6 did not
affect the activity of the
mitogen activated protein kinase
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells, Tak1 is not only required for TGF-ß- and
bone morphogenetic protein induced p38
Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads