UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to S100A8

S100A8 — TLR4

Pathways - manually collected, often from reviews:

NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: assay
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: assay
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: assay
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → MRP8/MRP14 complex (S100A8-S100A9) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → TLR4/MD2 complex (LY96-TLR4) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14 complex (S100A8-S100A9) → TLR4/MD2 complex (LY96-TLR4) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → IRAK (IRAK1) (modification, activates) Vogl et al., Nat Med 2007