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NOS2 — TLR7

Text-mined interactions from Literome

Brightbill et al., Science 1999 : Several lipoproteins stimulated TLR dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6, nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Tsukamoto et al., J Immunol 2008 : Previous pharmacologic studies have suggested that a PI3K-Akt pathway negatively regulates TLR induced inducible NO synthase expression and cytokine production
Masamune et al., J Gastroenterol 2008 : TLR ligands induced expression of monocyte chemoattractant protein 1, cytokine induced neutrophil chemoattractant 1 ( a rat homolog of interleukin-8 ), and inducible nitric oxide synthase , but not proliferation or type I collagen production
Lin et al., Mol Immunol 2010 : Nevertheless TLR mediated JNK activation as well as the increased protein expression of iNOS and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach