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CDC73 — NPPA

Text-mined interactions from Literome

Ais et al., Rev Esp Enferm Dig 1992 (Acute Disease...) : PAF-acether levels increased in plasma and peritoneal exudate of rats with ANP
Church et al., Am J Physiol 1994 : In this study we demonstrate that PAF , but not lyso-PAF, induces a concentration dependent increase in ANP secretion in spontaneously beating neonatal rat cardiomyocytes, a response associated with increases in cellular adenosine 3',5'-cyclic monophosphate ( cAMP ) formation, calcium influx, and the mobilization of calcium from intracellular stores ... cAMP formation and calcium influx appear to play major roles in PAF induced ANP secretion in this system, insofar as PAF induced ANP release was substantially reduced in the presence of the ( R ) -p-diastereoisomer of adenosine 3',5'-cyclic monophosphorothioate ( 10 microM ), whereas both PAF induced calcium influx and ANP secretion were abolished in the presence of the calcium channel antagonist nifedipine ( 0.1 microM ) ... Taken together, these results suggest that PAF , DBcAMP, and forskolin promote ANP secretion in spontaneously beating cardiomyocytes via the activation of a cAMP dependent, nifedipine-sensitive myocardial calcium channel and that calcium influx is a major requirement for cAMP induced ANP secretion in this system
Qu et al., J Physiol 1998 (Endotoxemia) : These results suggest that during endotoxaemia : ( a ) the spleen is the site of the highest endogenous PAF production ; ( b ) the initial release of ANP is dependent on the production of endogenous PAF, and a PAF-ANP interaction mediates the early plasma volume reduction ; ( c ) plasma volume reduction as well as ANP release depend on the spleen ; ( d ) PAF mediated the hypotensive response and its action in the spleen ; and ( e ) sequestered neutrophils are probably not the main source of PAF in the spleen