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IL12A — MAF
Text-mined interactions from Literome
Cao et al., J Immunol 2002
(Fibrosarcoma) :
Differential
regulation of
IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor
c-Maf fibrosarcoma
Homma et al., J Interferon Cytokine Res 2007
:
The Th2 transcription factor
c-Maf inhibits
IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation ... When overexpressed,
c-Maf can potently
suppress IL-12 production ... This study contributes to our understanding of the molecular basis of the homeostatic
regulation of
IL-12 production by
c-Maf , which plays a dual role both in the function of antigen presenting cells (APCs) and in T helper cell differentiation