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CDKN1B — TGFB1
Text-mined interactions from Literome
Yoon et al., Biochem J 2002
:
When neutralized with an anti- ( TGF-beta1 ) antibody, p27Kip1 induction was completely abolished, indicating that
TGF-beta1 is the major
inducer of
p27Kip1
Donovan et al., J Biol Chem 2002
:
Non-malignant and tumor derived cells differ in their
requirement for
p27Kip1 in
transforming growth factor-beta mediated G1 arrest
Sieczkiewicz et al., Microvasc Res 2003
:
TGF-beta 1 induces expression of the myogenic transcription factor myf-5 and the
cyclin dependent kinase inhibitor p27 ; we show that these signaling pathways are disrupted in the DNT beta RII bearing pericytes
Su et al., J Nephrol 2012
:
ATRA dose-dependently reversed both
TGF-beta1 induced decreases in p21Waf1/Cip1 mRNA and protein levels and
p27Kip1 protein level and increases in Skp2 mRNA and protein levels, and inhibited TGF-beta1 induced proliferation through G1 arrest
Ponce-CastaƱeda et al., Cancer Res 1995
(Neoplasms) :
These results argue that the often observed loss of antimitogenic
transforming growth factor beta responsiveness in human cancer cells is not
due to structural defects in
p27Kip1
Wolf et al., Am J Physiol 1997
(Hypertrophy) :
High glucose stimulated expression of
p27Kip1 involved activation of protein kinase C and was partly
dependent on induction of
transforming growth factor-beta ( TGF-beta )
Kamesaki et al., J Immunol 1998
(Lymphoma, B-Cell) :
This
TGF-beta1 mediated induction of p27Kip1 also
resulted in an increased association of
p27Kip1 with Cdk2 and a decreased Cdk2 kinase activity
Kim et al., Gynecol Oncol 1998
(Carcinoma...) :
Transforming growth factor-beta 1 induces apoptosis through down-regulation of c-myc gene and overexpression of
p27Kip1 protein in cervical carcinoma