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ICAM1 — MMP9

Text-mined interactions from Literome

Lee et al., J Allergy Clin Immunol 2003 (Asthma...) : An aim of this study was to evaluate the effect of MMP inhibitors on the expression of ICAM-1 and VCAM-1 in the migration of inflammatory cells in a murine model of TDI induced asthma ... We used a murine model to investigate TDI induced asthma to examine the possible involvement of ICAM-1 and VCAM-1 in the pathogenesis of that disease and the effect of MMP inhibitors on the expression of ICAM-1 and VCAM-1 ... These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta, IL-4, and TNF-alpha expression
Wang et al., Phytomedicine 2011 : 200 nM MMP-9 CD stimulated cardiac fibroblasts migration ( 169.4±22.5 % versus 100±0 %, p < 0.01 ), increased collagen synthesis ( 1.5±0.2 fold, p < 0.05 ), up-regulated the secretion of ICAM ( 574.0±40.1 versus 268.5±8.6pg/ml, p < 0.01 ), TNF-a ( 192.6±11.0 versus 14.4±1.8pg/ml, p < 0.001 ), IL-6 ( 1500.9±70.2 versus 323.4±40.6pg/ml, p < 0.001 ) and sVCAM-1 ( 30.3±4.3 versus 7.0±0.1 pg/ml, p < 0.05 ) and down-regulated VEGF ( 436.5±148.9 versus 1034.3±28.1 pg/ml, p < 0.05 ) significantly with modest effects on proliferation