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AIM2 — CASP8

Text-mined interactions from Literome

Lenert et al., Clin Exp Immunol 2010 (Lupus Erythematosus, Systemic) : Interestingly, AIM2 is not capable of inducing type I IFN, but rather plays a role in caspase I activation
Jones et al., Proc Natl Acad Sci U S A 2010 (Tularemia) : IFN-I did, however, boost AIM2 dependent caspase-1 activation by increasing AIM2 protein levels
Wu et al., J Clin Immunol 2010 (Listeriosis) : Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2 , NLRC4, and NLRP3 inflammasomes as well as the adaptor protein ASC all contribute to activation of caspase-1 in Listeria infected macrophages
Pierini et al., Cell Death Differ 2012 (Tularemia) : The adaptor molecule ASC mediates AIM2 dependent caspase-1 activation
Saiga et al., Int Immunol 2012 (Tuberculosis, Pulmonary) : Genomic DNA extracted from M. tuberculosis ( Mtb DNA ) induced caspase-1 activation and IL-1ß/IL-18 secretion in an AIM2 dependent manner
Ulland et al., Infect Immun 2013 (Tularemia) : Activation of the AIM2 inflammasome results in autocatalytic cleavage of caspase-1 , resulting in the processing and secretion of interleukin-1ß (IL-1ß) and IL-18, which play a crucial role in innate immune responses to F. tularensis
Dotson et al., J Biol Chem 2013 (Tularemia) : An enhanced activation of caspase-1 and IL-1ß observed in FTL_0325 mutant infected macrophages at 24 h post-infection was independent of both AIM2 and NLRP3