Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP8

CASP8 — CTSD

Text-mined interactions from Literome

Johansson et al., Cell Death Differ 2003 : Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
Emert-Sedlak et al., Mol Cancer Ther 2005 : Involvement of cathepsin D in chemotherapy induced cytochrome c release, caspase activation , and cell death ... Moreover, cathepsin D down-regulation significantly delayed cytochrome c release and caspase-3 activation in response to chemotherapy treatment
Stroikin et al., Biogerontology 2007 : Increase of lysosomal pH was significantly less prominent in lipofuscin loaded cells than in controls and was accompanied neither by leakage of cathepsin D nor by caspase-3 activation even 96 h after the initiation of starvation
Albee et al., J Leukoc Biol 2007 (Escherichia coli Infections) : Collectively, these data suggest that cathepsin D activation of caspase 3/7 may be required for inducing one of the death pathways elicited by E. coli
Lee et al., Neurochem Int 2007 (Parkinson Disease) : Cathepsin D (CD) and caspase-3 activity also increased following exposure to 6-OHDA
Conus et al., J Exp Med 2008 (Inflammation...) : Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation ... We describe a new proapoptotic pathway in which cathepsin D directly activates caspase-8 ... Pharmacological or genetic inhibition of cathepsin D resulted in delayed caspase activation and reduced neutrophil apoptosis
Padrón-Barthe et al., Biochim Biophys Acta 2008 : Cathepsin D enhances caspase activity in the cell by cleaving procaspase-8 and LEI overexpression slows down this cleavage, protecting cells from apoptosis
Conus et al., J Biol Chem 2012 : A direct and fast activation of caspase-8 by cathepsin D was shown to be crucial in the initial steps of neutrophil apoptosis ... At acidic pH, cathepsin D specifically cleaved caspase-8 but not the initiator caspase-9 or -10 and significantly increased caspase-8 activity in dimerizing conditions