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CREB1 — VEGFA

Text-mined interactions from Literome

Mayo et al., J Biol Chem 2001 : Binding of VEGF to the KDR/Flk1 receptor tyrosine kinase induces phosphorylation of the CRE binding protein ( CREB ) transcription factor on serine 133 and increases CREB DNA binding and transactivation ... Confocal microscopy shows that VEGF induced phosphorylation of nuclear CREB is blocked by pharmacological inhibition of protein kinase C and p38 mitogen activated protein kinase signaling
Rius et al., Atherosclerosis 2006 (Atherosclerosis) : VEGF induced CREB activation ( phosphorylation in Ser ( 133 ) )
Wu et al., Oncogene 2007 (Bone Neoplasms...) : cAMP-responsive element binding protein regulates vascular endothelial growth factor expression : implication in human prostate cancer bone metastasis ... Activation of CREB induced , whereas inhibition of CREB blocked, VEGF expression in ARCaP cells ... CREB may regulate VEGF transcription via a hypoxia-inducible factor dependent mechanism in normoxic conditions ... Activation of CREB signaling is involved in the coordinated regulation of VEGF and may pre-dispose to PCa bone metastasis
Jeon et al., Mol Cells 2007 : In the present study we investigated the possible role of CREB in the expression of vascular endothelial growth factor ( VEGF ) by mouse macrophages ... Over-expression of CREB increased VEGF secretion by cells of the RAW264.7 mouse macrophage cell line ... These results indicate that PKA phosphorylates CREB and so induces VEGF gene expression ... An analysis of mutant promoters revealed that one of the putative CREB responsive elements ( CREs ), at 399 approximately 388 in the promoter, is critical for CREB mediated VEGF promoter activity, and the significance of this CRE was confirmed by chromatin immunoprecipitation assays
Ma et al., J Asian Nat Prod Res 2008 (Neoplasms...) : Beta-eudesmol ( 100 microM ) also blocked the phosphorylation of cAMP response element binding protein ( CREB ) induced by VEGF ( 30 ng/ml ) in HUVEC
Atsuta et al., Int J Cardiol 2009 : Overexpression of CREB ( cAMP-responsive element binding protein ) induces VEGF promoter and reduces PAI-1 promoter activities
Scoditti et al., Cardiovasc Res 2010 : As both protein kinase C (PKC)alpha and beta are involved in VEGF induced COX-2 expression and CREB activation, we investigated which isoform ( s ) of PKC was affected by RSG ... VEGF induces CREB mediated COX-2 expression through a PKCalpha dependent pathway in human endothelium ... The anti-angiogenic effect of PPARgamma agonists is due, at least in part, to an interference with the VEGF stimulated PKCalpha mediated activation of CREB and the related expression of COX-2
Lee et al., J Neurochem 2010 (Anoxia...) : Inhibiting VEGFR-2 and extracellular signal regulated kinase ( ERK ), respectively, reduced VEGF-A induced CREB phosphorylation and protection of H19-7 and b.End3 cells against OGD
Lu et al., Cell Mol Life Sci 2010 (Carcinoma, Squamous Cell) : Inhibition of vascular endothelial growth factor-A ( VEGF-A ) in the microenvironment with its antibody blocked the endothelial-like differentiation and the phosphorylation of MAPK/ERK1/2 and CREB
Zhao et al., Int J Cancer 2011 (Neovascularization, Pathologic) : Moreover, using pharmacological inhibitors and molecular approaches, we show that VEGF induced CREB activation is largely mediated by protein kinase C-dependent protein kinase D activation
Tripathi et al., Mol Cell Biochem 2012 (MAP Kinase Signaling System...) : The analyses of the phosphorylated transcription factors revealed that ANP inhibited VEGF stimulated activation of CREB , and the AP-1 subunits ( c-jun and c-fos ) ... The addition of the protein kinase G ( PKG ) inhibitor, KT-5823, restored the VEGF stimulated activation of MAPKs, AP-1, and CREB , demonstrating the integral role of cGMP/PKG signaling in NPRA mediated effects