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HSPG2 — PTX3

Text-mined interactions from Literome

Melien et al., J Cell Physiol 2000 : Under the same conditions, PTX did not affect agonist stimulation of phosphoinositide-specific phospholipase C ( PI-PLC ) ( IP ( 3 ) generation ), and did not reduce the activation by these agents of phospholipase D ( PLD )
Zhou et al., Am J Physiol Cell Physiol 2004 : PLC-beta activity was partially inhibited by pertussis toxin ( PTX ) , Gbeta or Galpha ( q ) antibody, PLC-beta1 or PLC-beta3 antibody, and by expression of Galpha ( q ) or Galpha ( i ) minigene, and was abolished by a combination of antibodies or minigenes
Kawakami et al., Arterioscler Thromb Vasc Biol 2007 : Pertussis toxin ( PTX ) inhibited apoCIII induced PC-PLC activation and subsequent PKC alpha activation, implicating PTX-sensitive G protein pathway
Meshki et al., Purinergic Signal 2006 : However, the PLC inhibitor U73122 almost completely inhibited Ca ( 2+ ) mobilization in both nucleotide- and fMLP stimulated neutrophils, strongly supporting the view that both the PTX-sensitive and the PTX-insensitive mechanism of Ca ( 2+ ) increase require activation of PLC
O'Mullane et al., Clin Exp Pharmacol Physiol 2009 : 4. Stimulation of apical P2Y2Rs also activates an additional signalling mechanism that inhibits the ENaC and involves the activated Galpha subunit of a PTX-insensitive G-protein and activation of an unidentified PLC
Zhu et al., Proc Natl Acad Sci U S A 1996 : ( iv ) Activation of expressed receptors by their respective ligands in cells coexpressing excess Gbeta gamma elicited agonist stimulated PLC activities, which, in the case of the M2R, was not blocked by pertussis toxin ( PTX ) , suggesting mediation by a PTX-insensitive PLC stimulating Galpha subunit, presumably, but not necessarily, of the Gq family
Joshi et al., FEBS Lett 1998 : Only the qi5 mediated stimulation of PI-PLC by kappa-opioids was partially inhibited by PTX