◀ Back to SHC1

PIK3R1 — SHC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1) → SHC/GRB2/SOS1/GAB1 complex (SHC1-GRB2-SOS1-GAB1) (modification, collaborate)
  Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/GRB2/SOS1/GAB1 complex (SHC1-GRB2-SOS1-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
  Evidence: assay, other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PKC zeta (PRKCZ) (modification, activates) Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: SHC/GRB2/SOS1 complex (SOS1-GRB2-SHC1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Mäkinen et al., EMBO J 2001, Salameh et al., Blood 2005
  Evidence: assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Angiopoietin receptor Tie2-mediated signaling: Tie2/Ang1/Shc complex (ANGPT1-TEK-SHC1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Fujikawa et al., Exp Cell Res 1999, Audero et al., J Biol Chem 2004, Kontos et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta4 Integrin/Met complex (ITGA6) → alpha6/beta4 Integrin/Met /SHC/PI3K complex (ITGA6-SHC1-PIK3CA-PIK3R1) (modification, collaborate)
  Trusolino et al., Cell 2001
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: PI3K complex (PIK3CA-PIK3R1) → SHC (SHC1) (modification, collaborate) Trusolino et al., Cell 2001
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: PI3K complex (PIK3CA-PIK3R1) → alpha6/beta4 Integrin/Met /SHC/PI3K complex (ITGA6-SHC1-PIK3CA-PIK3R1) (modification, collaborate)
  Trusolino et al., Cell 2001
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: SHC (SHC1) → alpha6/beta4 Integrin/Met /SHC/PI3K complex (ITGA6-SHC1-PIK3CA-PIK3R1) (modification, collaborate)
  Trusolino et al., Cell 2001
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma: None → SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1) (modification, collaborate)
  
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, other species
• NCI Pathway Database EPO signaling pathway: SHC (SHC1) → GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1) (modification, collaborate)
  
• NCI Pathway Database EPO signaling pathway: SHC (SHC1) → PIK3R1 (PIK3R1) (modification, collaborate)
• NCI Pathway Database EPO signaling pathway: Gab1 (GAB1) → GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1) (modification, collaborate)
  
• NCI Pathway Database EPO signaling pathway: GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1) → PIK3R1 (PIK3R1) (modification, collaborate)
• NCI Pathway Database EPO signaling pathway: GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1) → SHP2 (PTPN11) (modification, collaborate)
• NCI Pathway Database EPO signaling pathway: GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1) → SHIP (INPP5D) (modification, collaborate)
• NCI Pathway Database SHP2 signaling: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype
• Reactome Reaction: PIK3R1 → SHC1 (reaction) Nishida et al., Blood 1999, Wickrema et al., J Biol Chem 1999, Yu et al., J Immunol 2006, Nishida et al., J Immunol 2011, Gu et al., Mol Cell 1998
• Reactome Reaction: PIK3R1 → SHC1 (indirect_complex) Nishida et al., Blood 1999, Yu et al., J Immunol 2006, Nishida et al., J Immunol 2011

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: PIK3R1 — SHC1 (coimmunoprecipitation) Fukazawa et al., J Biol Chem 1996
• IRef Biogrid Interaction: PIK3R1 — SHC1 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Biogrid Interaction: PIK3R1 — SHC1 (physical association, affinity chromatography technology) Ren et al., Exp Hematol 2005*
• IRef Biogrid Interaction: PIK3R1 — SHC1 (physical association, affinity chromatography technology) Cerboni et al., Eur J Immunol 1998*
• IRef Biogrid Interaction: PIK3R1 — SHC1 (direct interaction, pull down) Harrison-Findik et al., Oncogene 1995*
• IRef Biogrid Interaction: PIK3R1 — SHC1 (direct interaction, pull down) Ren et al., Mol Cell Biol 2005*
• IRef Hprd Interaction: SHC1 — PIK3R1 (in vivo) Ren et al., Exp Hematol 2005*, Panchamoorthy et al., J Biol Chem 1996, Fukazawa et al., J Biol Chem 1996
• IRef Hprd Interaction: SHC1 — PIK3R1 (in vitro) Ren et al., Exp Hematol 2005*, Panchamoorthy et al., J Biol Chem 1996, Fukazawa et al., J Biol Chem 1996
• IRef Intact Interaction: Complex of UBASH3B-SHC1-PCCB-MCCC2-GRB2-INPPL1-CBL-PIK3R1-PIK3R2 (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of CSF2RB-SHC1-PIK3R1-CSF2RB-SHC1-CSF2RB-PIK3R1-PIK3R1-SHC1 (association, pull down) Guthridge et al., EMBO J 2006
• IRef Intact Interaction: Complex of 40 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 13 proteins (association, pull down) Wang et al., Cancer Cell 2006
• IRef Intact Interaction: Complex of 28 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 37 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: SHC1 — PIK3R1 (physical association, proximity ligation assay) Liu et al., Mol Cell Proteomics 2013
• IRef Intact Interaction: SHC1 — PIK3R1 (physical association, coimmunoprecipitation) Panchamoorthy et al., J Biol Chem 1996
• IRef Intact Interaction: SHC1 — PIK3R1 (physical association, coimmunoprecipitation) Fukazawa et al., J Biol Chem 1996
• IRef Intact Interaction: SHC1 — PIK3R1 (physical association, pull down) Ren et al., Exp Hematol 2005*
• IRef Intact Interaction: Complex of PIK3R1-SHC1-ERBB2-ERBB3-EGFR (association, pull down) Wang et al., Cancer Cell 2006
• IRef Ophid Interaction: SHC1 — PIK3R1 (aggregation, confirmational text mining) Fukazawa et al., J Biol Chem 1996
• IRef Ophid Interaction: SHC1 — PIK3R1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ramshaw et al., Blood 2007 : These results reveal a previously unrecognized negative signaling role for Tyr577 in beta ( c ) and demonstrate that uncoupling Shc from cytokine receptors enhances PI3K signaling as well as survival and proliferation
Radhakrishnan et al., J Biol Chem 2008 (MAP Kinase Signaling System) : In contrast to MAPK activation the role of Shc in modulating PI3K in response to IGF-I has not been determined
Lee et al., J Biol Chem 2010 : OSS induced activation of PI3K/Akt/mTOR/p70S6K and cell proliferation were inhibited by specific antibodies or small interference RNAs of alpha ( v ) beta ( 3 ) and beta ( 1 ) integrins and by dominant negative mutants of Shc ( Shc-SH2 ) and focal adhesion kinase ( FAK ) ( FAK ( F397Y ) )