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CASP4 — HGF

Text-mined interactions from Literome

Nakagami et al., Diabetes 2002 : High D-glucose significantly increased bax protein, but not bcl-2, and activated caspase 3-like and 9, whereas HGF significantly increased bcl-2 expression without affecting bax level and attenuated the increase in caspase 3 and 9 activity
Sun et al., J Neurosci 2002 (Amyotrophic Lateral Sclerosis...) : HGF prevented induction of caspase-1 and inducible nitric oxide synthase (iNOS) in motoneurons and retained the levels of the glial-specific glutamate transporter ( excitatory amino acid transporter 2/glutamate transporter 1 ) in reactive astrocytes
Kuenzler et al., J Pediatr Surg 2002 (Reperfusion Injury) : This study investigated the effects of HGF on tissue levels of caspase-8 , an apoptosis initiator, and caspase-3, an apoptosis effector, in intestinal mucosa after IR
Schulze-Bergkamen et al., Hepatology 2004 : HGF significantly inhibited CD95 mediated apoptosis of PHH as well as cleavage of caspase-8 and poly ( ADP-ribose ) polymerase
Jin et al., Invest Ophthalmol Vis Sci 2005 : BSO activated caspase-3 , and this effect was significantly blocked by HGF
Del Bravo et al., J Androl 2007 : The antiapoptotic effect of HGF is mediated by caspase-3 activity because the amount of the active fragment of the enzyme is decreased in Leydig cells cultured in the presence of HGF
Kadoyama et al., Neurosci Res 2007 (Amyotrophic Lateral Sclerosis...) : HGF overexpression attenuated monocyte chemoattractant protein-1 ( MCP-1 ) induction, predominantly in astrocytes ; suppressed activation of caspase-1 , -3 and -9 ; and, increased X chromosome linked inhibition of apoptosis protein ( XIAP ) in the motoneurons of G93A mice
Chen et al., Stem Cells Dev 2011 (Acute Kidney Injury...) : Real-time polymerase chain reaction result showed that HGF-hucMSCs also inhibited caspase-3 and interleukin-1ß mRNA expression in injured renal tissues
Lee et al., Mol Biol Cell 2010 : HGF also blocked Ang II-induced caspase-3 activation and lactate dehydrogenase release in tissue explants in an ERK dependent manner
Arakaki et al., Biochem Biophys Res Commun 1998 (Sarcoma) : Both HGF induced DNA fragmentation and caspase-3 activity were completely inhibited by co-incubation with an inhibitor of caspase-3, Ac-DEVD-H ... Hepatocyte growth factor , which is now known to be the same protein as scatter factor, induced oligonucleosomal fragmentation of nuclear DNA of Sarcoma 180 cells and increased the activity of caspase-3 , a key component in control of the apoptotic cell death pathway to about 2.6 times that in control cells on 48 hr incubation, but did not increase the activity of caspase-1