Zhang et al., J Neurosci 2007
(Alzheimer Disease...) :
Progranulin mediates caspase dependent cleavage of TAR DNA binding protein-43 Suzuki et al., J Biol Chem 2011
(Amyotrophic Lateral Sclerosis...) :
Accumulated evidence indicates that caspases are activated in neurons of ALS and FTLD-U patients, and activated caspase mediated cleavage of TDP-43 generates CTFs of TDP-43
Cassel et al., Biochimie 2012
:
Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function ... Here we examine the effects of a series of 4-aminoquinolines with affinity for TDP-43 upon caspase-7 induced cleavage of TDP-43 and TDP-43 cellular function ... Incubation of TDP-43 and caspase-7 in the presence of these compounds stimulated caspase-7 mediated cleavage of TDP-43