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FGF3 — ZEB2

Text-mined interactions from Literome

Dang et al., Neural development 2010 (MAP Kinase Signaling System) : FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm ... Here we tested whether FGF and Wnt signaling pathways can regulate Zfhx1b expression to control early neural stem cell development ... Our data suggest that definitive NSC fate specification in the mouse neurectoderm is facilitated by FGF activation of Zfhx1b
Katoh et al., Curr Pharm Biotechnol 2011 : Because FGF , Hedgehog, TGFß, and non-canonical WNT signals synergistically induce EMT regulators, such as Snail ( SNAI1 ), Slug ( SNAI2 ), TWIST, and ZEB2 ( SIP1 ), tumor-stromal interaction at the invasion front aids cancer stem cells to acquire more malignant phenotype
Dang et al., Stem Cells Dev 2012 : Zfhx1b gene expression is rapidly upregulated in mouse ES cells cultured in a permissive neural inducing environment, compared to ES cells in a standard pluripotency maintenance environment, and is potentiated by FGF signalling ... Thus, our findings using ES cells are congruent with evidence from mouse embryos and support a model, whereby intercellular FGF signaling induces Zfhx1b , which promotes the development of definitive NSCs subsequent to an initial neural specification event that is independent of this pathway