Maddens et al., Blood 2002
:
In contrast, phospholipase C gamma (PLC gamma) inhibition by U73122 totally restored IR-induced N-SMase stimulation, ceramide production, and apoptosis in Kit activated cells
Cifone et al., EMBO J 1995
(Lymphoma) :
Activation of a phosphatidylcholine-specific phospholipase C ( PC-PLC ) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1 induced aSMase activation, but not Fas/APO-1 induced neutral sphingomyelinase (nSMase) activation