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CDK10 — HDAC1
Text-mined interactions from Literome
Hitomi et al., FEBS Lett 2003
:
Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and
activate the
cyclin dependent kinase inhibitor, p21 ( WAF1/Cip1 )
Li et al., Cancer Res 2010
(Colonic Neoplasms) :
HDAC depletion relieved
HDAC mediated transcriptional inhibition of the
cyclin dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G(2) phase of the cell cycle
Findeisen et al., Arterioscler Thromb Vasc Biol 2011
(Disease Models, Animal...) :
HDAC inhibition
resulted in a transcriptional and posttranscriptional regulation of the
cyclin dependent kinase inhibitors p21 ( Cip1 ) and p27 ( Kip )
Veliz et al., Cancer Control 2012
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
These investigational agents include rituximab, alemtuzumab, ofatumumab, bendamustine, high-dose methylprednisolone, lenalidomide, lumiliximab,
cyclin dependent kinase inhibitors, small modular immunopharmaceuticals, Bcl-2 inhibitors, and
histone deacetylase inhibitors