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FABP4 — PPARG
Pathways - manually collected, often from reviews:
-
KEGG PPAR signaling pathway:
Complex of PPARG-RXRA-RXRB-RXRG
→
FABP4
(gene expression, expression)
-
Reactome Reaction:
FABP4
→
PPARG
(reaction)
Gelman et al., J Biol Chem 1999, Farmer et al., Cell Metab 2006, Lambe et al., Eur J Biochem 1996, Lemberger et al., Annu Rev Cell Dev Biol 1996, Mukherjee et al., J Biol Chem 1997
-
WikiPathways PPAR signaling pathway:
Complex of PPARG-RXRA-RXRG-RXRB
→
ANGPTL4/ADIPOQ/PLIN1/MMP1/MMP1/SORBS1/FABP4
(mim-transcription-translation)
Text-mined interactions from Literome
Tan et al., Mol Cell Biol 2002
:
We show that adipocyte FABP and keratinocyte
FABP ( A-FABP and K-FABP, respectively ) selectively
enhance the activities of
PPARgamma and PPARbeta, respectively, and that these FABPs massively relocate to the nucleus in response to selective ligands for the PPAR isotype which they activate
Fu et al., Atherosclerosis 2002
(Arteriosclerosis) :
The induction of
ALBP by oxLDL probably
involved activation of peroxisome proliferator activated receptor gamma (
PPARgamma ) transcription factors, since four different endogenous PPARgamma ligands, including 9-hydroxyoctadecadienoic acid ( 9-HODE ) and 13-hydroxyoctadecadienoic acid ( 13-HODE ), two oxidized lipid components of oxLDL, as well as 15-deoxy-delta12,14 prostaglandin J2 ( 15d-PGJ2 ) and retinoic acid ( RA ), all induced ALBP expression in macrophage/foam cells
Damcott et al., Metabolism 2004
(Insulin Resistance) :
In turn, FABP4 binds fatty acids and transports them to the nucleus where the
FABP4/fatty acid complex
activates PPARgamma in a positive feedback loop
Ayers et al., Biochemistry 2007
:
Continuous nucleocytoplasmic shuttling underlies transcriptional
activation of
PPARgamma by
FABP4 ... The data demonstrate that both nuclear export and nuclear import are critical for enabling
FABP4 to
enhance the transcriptional activity of
PPARgamma