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ITGAM — SELP

Pathways - manually collected, often from reviews:

• NCI Pathway Database amb2 Integrin signaling: P-selectin oligomer complex (SELP) → alphaM/beta2 Integrin/P-Selectin/PSGL1 complex (ITGAM-ITGB2-SELPLG-SELP) (modification, collaborate)
  Ma et al., Blood 2004*, Evangelista et al., Blood 1999*
  Evidence: mutant phenotype, assay
• NCI Pathway Database amb2 Integrin signaling: P-selectin oligomer complex (SELP) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
  Ma et al., Blood 2004*, Evangelista et al., Blood 1999*
  Evidence: mutant phenotype, assay
• NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/P-Selectin/PSGL1 complex (ITGAM-ITGB2-SELPLG-SELP) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
  Ma et al., Blood 2004*, Evangelista et al., Blood 1999*
  Evidence: mutant phenotype, assay
• NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/P-Selectin/PSGL1 complex (ITGAM-ITGB2-SELPLG-SELP) → PSGL1 (SELPLG) (modification, collaborate) Ma et al., Blood 2004*, Evangelista et al., Blood 1999*
  Evidence: mutant phenotype, assay
• NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/P-Selectin/PSGL1 complex (ITGAM-ITGB2-SELPLG-SELP) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (leukocyte adhesion, collaborate)
  Piccardoni et al., Blood 2001
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Rinder et al., Circulation 1999 : Samples were assayed for C3a and C5b-9, monocyte activation ( CD11b upregulation ), PMN activation ( CD11b upregulation and elastase release ), and platelet activation ( P-selectin expression and monocyte-platelet conjugate formation )
Li et al., Circulation 1999 (Thrombosis) : Aspirin markedly reduced the urinary excretion of 11-dehydrothromboxane B ( 2 ), decreased P-selectin expression in single platelets at rest ( P < 0.05 ), and inhibited fMLP induced neutrophil CD11b expression, but it did not attenuate exercise induced increases in platelet aggregability, platelet P-selectin expression, leukocyte CD11b expression, platelet-leukocyte aggregate formation, soluble P-selectin , or prothrombin fragment 1+2
Li et al., Journal of thrombosis and haemostasis : JTH 2006 : P-Lym formation initiated by platelet activation was abolished by P-selectin blockade, and tended to be reduced by inhibition of GPIIb/IIIa, CD11b , or CD40L
Elstad et al., J Immunol 1995 : P-selectin did not stimulate increased surface expression of integrin CD11b/CD18 and did not enhance binding of iC3b coated erythrocytes, a CD11b/CD18 mediated functional response