We have a suspicion that you are an automated web bot software, not a real user.
To keep our site fast for other users, we have slowed down this page.
The slowdown will gradually disappear.
If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu.
Also note that all data for hgGeneGraph can be obtained through our public MySQL server and
all our software source code is available and can be installed locally onto your own computer.
If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
JavaScript is disabled in your web browser
You must have JavaScript enabled in your web browser to use the Genome Browser
Gene interactions and pathways from curated databases and text-mining
◀ Back to MYC
GFI1 — MYC
Pathways - manually collected, often from reviews:
FastForward regulation :
GFI1
→
MYC
(transcriptional regulation, increase)
Laurent et al., Stem Cells 2009 *
DNABINDING
NCI Pathway Database Validated targets of C-MYC transcriptional repression :
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(transcription, activates)
Claassen et al., Proc Natl Acad Sci U S A 2000 , Seoane et al., Nature 2002 , Wu et al., Oncogene 2003 , Brenner et al., EMBO J 2005 , Liu et al., Oncogene 2010
mutant phenotype, assay, reporter gene, physical interaction
NCI Pathway Database Validated targets of C-MYC transcriptional repression :
DNMT3A (DNMT3A)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(modification, collaborate)
Brenner et al., EMBO J 2005 , Liu et al., Oncogene 2010
mutant phenotype, physical interaction
NCI Pathway Database Validated targets of C-MYC transcriptional repression :
GFI1 (GFI1)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Brenner et al., EMBO J 2005 , Liu et al., Oncogene 2010
mutant phenotype, physical interaction
NCI Pathway Database Validated targets of C-MYC transcriptional repression :
GFI1 (GFI1)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(modification, collaborate)
Brenner et al., EMBO J 2005 , Liu et al., Oncogene 2010
mutant phenotype, physical interaction
NCI Pathway Database Validated targets of C-MYC transcriptional repression :
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(modification, collaborate)
Brenner et al., EMBO J 2005 , Liu et al., Oncogene 2010
mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *