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MYC — NPM1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yeh et al., Mol Pharmacol 2006
(Urinary Bladder Neoplasms) :
Higher expression of Ras, c-Myc, and nucleophosmin/B23 and greater
c-Myc transactivation and
nucleophosmin/B23 promoter activities were detected in U1 cells compared with U4 cells ... Our results indicate that Ras and
c-Myc play important roles in the up-regulation of
nucleophosmin/B23 during proliferation of cells associated with a high degree of malignancy, thus outlining a signaling cascade involving these factors in the cancer cells
Li et al., Oncogene 2013
:
Nucleophosmin is
essential for
c-Myc nucleolar localization and c-Myc mediated rDNA transcription ... Conversely, high transient
NPM expression
enhances c-Myc nucleolar localization, leading to increased c-Myc proteolysis ... Taken together, these results demonstrate an essential
role for
NPM in
c-Myc nucleolar localization and c-Myc mediated rDNA transcription