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MYC — SKP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → Complex of CUL1-RBX1-SKP1-SKP2 (increases, CUL1/RBX1/SKP1/SKP2 Activity)
  
  Evidence: It has been reported that during the G1 to S transition of the cell cycle, Skp2 regulates the ubiquitinylation and stability of the transcription factor c-Myc, an oncoprotein that plays a major role in oncogenesis Skp2 enhances c-Myc-induced S phase transition and activates c-Myc transcriptional activity.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — SKP1 (physical association, affinity chromatography technology) von der Lehr et al., Cell cycle (Georgetown, Tex.) 2003*
• IRef Biogrid Interaction: MYC — SKP1 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: MYC — SKP1 (physical association, affinity chromatography technology) Koch et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Intact Interaction: SKP1 — MYC (physical association, two hybrid array) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: Complex of 222 proteins (association, tandem affinity purification) Koch et al., Cell cycle (Georgetown, Tex.) 2007