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PLAUR — SLC22A3

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Jo et al., J Biol Chem 2009 : uPAR overexpression in cancer cells also promotes EMT
Jo et al., Cancer Res 2010 (Breast Neoplasms) : Whereas uPAR overexpression did not induce EMT in MCF-7 breast cancer cells, CSC-like properties were nevertheless still induced along with an increase in tumor initiation and growth in the orthotopic setting in SCID mice
Gupta et al., Int J Oncol 2011 (Cerebellar Neoplasms...) : Downregulation of uPA/uPAR inhibits intermittent hypoxia induced epithelial-mesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells ... Moreover, hypoxia/ overexpression of uPAR in cancer cells promote the epithelial-mesenchymal transition (EMT) and thereby invasiveness and metastasis
Wang et al., Respir Res 2013 (Pulmonary Disease, Chronic Obstructive) : In this study, we investigated the degree of EMT and uPAR expression in lung epithelium of COPD patients, and verified the effect of uPAR on cigarette smoke extract (CSE) induced EMT in vitro ... The role of uPAR on CSE induced EMT in human small airway epithelial cells ( HSAEpiCs ) was assessed by silencing uPAR expression in vitro ... In vitro, CSE induced EMT in HSAEpiCs was associated with high expression of uPAR, and targeted silencing of uPAR using shRNA inhibited CSE induced EMT ... Finally, we demonstrate that the PI3K/Akt signaling pathway is required for uPAR mediated EMT in HSAEpiCs