Gene interactions and pathways from curated databases and text-mining

◀ Back to E2F1

E2F1 — MAPK8

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: E2F1 → MAPK8 (decreases, MAPK8 Activity, E2F1 Activity)
    Evidence: JNK1 phosphorylates E2F1 in vitro, and co-transfection of JNK1 reduces the DNA binding activity of E2F1;
  • OpenBEL Selventa BEL large corpus: E2F1 → MAPK8 (increases, E2F1 Activity)
    Evidence: JNK1 phosphorylates E2F1 in vitro, and co-transfection of JNK1 reduces the DNA binding activity of E2F1;

Text-mined interactions from Literome

Kishore et al., Circ Res 2003 : In this study, we report that c-Jun N-terminal kinase (JNK) 1 and p38 mitogen activated protein kinases ( MAPKs ) are differentially required for E2F1 expression and activity in ECs
Hershko et al., J Biol Chem 2006 : We show here that E2F1 modulates the activity of the p38 MAPK pathway via E2F1 induced transient up-regulation of p38 MAPK phosphorylation