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E2F1 — RBBP4

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: PRMT5 (PRMT5) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (transcription, inhibits)
  Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (transcription, activates)
  Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RBBP4 — E2F1 (physical association, affinity chromatography technology) Nicolas et al., J Biol Chem 2000*

Text-mined interactions from Literome

Zhang et al., Nucleic Acids Res 2005 : The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription ... Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes
Duan et al., Prostate 2013 (Prostatic Neoplasms) : While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and involves E2F and histone H3K4me3 methylase MLL1 complex