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CPOX — MAPK1

Text-mined interactions from Literome

Nagano et al., Int Immunol 2002 : Therefore, we conducted this study to determine whether MAPK activation could be involved in prostaglandin E ( 2 ) ( PGE ( 2 ) ) production and cyclooxygenase (COX)-2 expression in LPS stimulated human neutrophils
Chen et al., Blood 2004 : Inhibition of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) pathway signaling by CsA may be responsible for the CsA mediated effects on the regulation of chemokine receptor and cyclooxygenase-2 (COX-2) expression
Englesbe et al., J Vasc Surg 2004 : We further demonstrated that p38 MAPK is activated by IL-1beta and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB ... IL-1beta inhibits PDGF-BB induced migration by cooperating with PDGF-BB to induce COX2 through activation of p38 MAPK
Studer et al., J Orthop Res 2005 : p38 MAPK inhibition and COX2 inhibition have unique and similar abilities to counteract some of the effects of IL-1 on human chondrocyte/cartilage metabolism
Araki et al., Free Radic Biol Med 2005 : PLA2, COX , PKC, NADH dehydrogenase, and XO inhibitors prevented the CA-induced ROS generation but not ERK 1/2, PI 3 K, p38 MAPK , and MLCK inhibitors
Grishin et al., J Immunol 2006 (Disease Models, Animal...) : Previously, we described LPS induced p38 MAPK dependent expression of cyclooxygenase-2 (COX-2) in rat IEC-6 cells ... In IEC-6 enterocytes, COX-2 was induced by the expression of MAPK kinase 3 EE ( MKK3EE ) , a constitutive activator of p38, but not of activators of ERK or JNK pathways
Reckamp et al., Clin Cancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : Overexpression of cyclooxygenase-2 (COX-2) activates extracellular signal regulated kinase/mitogen activated protein kinase signaling in an epidermal growth factor receptor (EGFR) tyrosine kinase inhibition ( TKI ) -resistant manner
Song et al., Mol Cells 2006 : We investigated the possible role of p38 MAPK and ETB receptors in ET-1 induction of cyclooxygenase-2 (COX-2) and prostaglandin E2 ( PGE2 ) in cultured feline esophageal smooth muscle cells ( ESMC )
Rodríguez et al., Cell Signal 2008 : In addition, the increase in COX2 expression and the activation of Erk1/2 regulated by Cot are essential for the induction of cell migration
Liao et al., Toxicol Lett 2009 : Moreover, COX-2 gene expression might be regulated by activated p38 MAPK in another unknown regulation pathway
Matzkin et al., Mol Cell Endocrinol 2012 (MAP Kinase Signaling System) : Our studies suggest that PRL induces COX2/PGs in hamster Leydig cells through IL-1ß and activation of P38-MAPK and JAK2
Gutiérrez-Venegas et al., Mol Biol Rep 2013 (Chronic Periodontitis) : We studied the role of the flavonoids fisetin, luteolin, myricetin, and morin in inhibiting the activation of mitogen activated protein kinase ( MAPK ) and AKT as well as their role in lipopolysaccharide (LPS) induced cyclooxygenase-2 (COX-2) transcription
Ridley et al., FEBS Lett 1998 : The mechanism by which p38 mitogen activated protein kinase ( MAPK ) regulates the induction of cyclooxygenase (COX)-2 by interleukin-1 (IL-1) has been investigated in HeLa cells